RESUMO
The recent type A foot and mouth disease virus field isolates recovered in India are shown to be antigenically quite divergent from the in-use vaccine strain (IND 17/82), warranting the selection of a suitable vaccine strain which can cover this diversity in antigenic spectrum. In earlier studies employing neutralization test with anti-146S rabbit sera raised against eight candidate vaccine strains, IND 81/00 and IND 40/00 belonging to genotype VII were found to offer the best antigenic coverage. In order to assess the credibility of IND 81/00 and IND 40/00 as vaccine strains, 17 recent isolates received during 2005-2006 and representative isolates from older genotypes were subjected to two-dimensional micro-neutralization assay using bovine convalescent serum (against IND 81/00 and IND 40/00) and bovine vaccinate serum (against IND 40/00). From the results it is evident that both the isolates IND 81/00 (antigenic relationship 'r-value' >0.40 with 86% of isolates) and IND 40/00 ('r-value' >0.40 with 78% of isolates) show nearly equal antigenic relatedness with the recent field viruses and hence both of these are effective vaccine candidates in present context. Though very limited in its extent, these useful data obtained with antisera raised in homologous host system are logical extension of the on going quest for the appropriate vaccine strain and circumvents species disparities in the immune recognition of epitopes.
Assuntos
Vírus da Febre Aftosa/classificação , Vírus da Febre Aftosa/imunologia , Febre Aftosa/prevenção & controle , Filogenia , Vacinas Virais/normas , Sequência de Aminoácidos , Animais , Variação Antigênica , Antígenos Virais/genética , Bovinos , Doenças dos Bovinos/epidemiologia , Doenças dos Bovinos/prevenção & controle , Doenças dos Bovinos/virologia , Febre Aftosa/epidemiologia , Febre Aftosa/virologia , Vírus da Febre Aftosa/genética , Genótipo , Soros Imunes/imunologia , Índia/epidemiologia , Dados de Sequência Molecular , Testes de Neutralização/veterinária , Coelhos , Homologia de Sequência de Aminoácidos , Sorotipagem/veterinária , Especificidade da Espécie , Vacinas Virais/imunologiaRESUMO
India due to its geographical location, has 5,700 kms long coastal line in the southern hemisphere of the earth. It faces four to five cyclones every year. Out of which one or two are very severe. Cyclones impact 50 per cent of population of the country. Due to complexities of cyclonic winds and their dynamic nature, behavior of buildings and their response can not be predicted on theoretical analysis only. In fact, this needs to be studied historically to improve design of buildings. SERC, Chennai has pioneered in the same and have arrived at specific guidelines and findings for structural improvements in residential as well as other buildings preventing devastating impacts. Some extracts of such findings and guidelines have been brought out on this paper. (AU)
