Detection of the SARS-CoV-2 spike protein in saliva with Shrinky-Dink(C) electrodes

Using the childrens toy, Shrinky-Dink (C), we present an aptamer-based electrochemical (E-AB) assay that recognizes the spike protein of SARS-CoV-2 in saliva for viral infection detection. The low-cost electrodes are implementable at population scale and demonstrate detection down to 0.1 fg mL-1 of the S1 subunit of the spike protein.