RESUMO
Benign neutropenia, observed in different ethnic groups, is the most common form of neutropenia worldwide. A specific single nucleotide polymorphism, rs2814778, located at the promoter of the ACKR1 (previously termed DARC) gene, which disrupts a binding site for the GATA1 erythroid transcription factor, resulting in a ACKR1-null phenotype, was found to serve as a predictor of low white blood cell and neutrophil counts in African-Americans and Yemenite Jews. Individuals with benign neutropenia due to the ACKR1-null allele have been found to have an increased susceptibility to human immunodeficiency virus infection and, on the other hand, a protective effect against malaria. The associated protective effect may explain the spread of the ACKR1-null allele by natural selection. The reviewed relationships between ACKR1 polymorphism and various pathological states may have important clinical implications to individuals with and without benign neutropenia. Potential mechanisms for ACKR1 (previously termed DARC) modulation during neutrophil recruitment to inflammation, and chemokine bioavailability in the circulation and in local tissue are reviewed and discussed.
Assuntos
Sistema do Grupo Sanguíneo Duffy , Fator de Transcrição GATA1 , Neutropenia , Polimorfismo de Nucleotídeo Único , Receptores de Superfície Celular , Elementos de Resposta/imunologia , Sistema do Grupo Sanguíneo Duffy/genética , Sistema do Grupo Sanguíneo Duffy/imunologia , Fator de Transcrição GATA1/genética , Fator de Transcrição GATA1/imunologia , Predisposição Genética para Doença , Infecções por HIV/genética , Infecções por HIV/imunologia , Infecções por HIV/patologia , HIV-1/imunologia , Humanos , Malária/genética , Malária/imunologia , Malária/patologia , Neutropenia/genética , Neutropenia/imunologia , Neutropenia/patologia , Neutrófilos/imunologia , Neutrófilos/patologia , Receptores de Superfície Celular/genética , Receptores de Superfície Celular/imunologiaRESUMO
INTRODUCTION: Short text: Click here for article written by Naama Rappoport, Neta Gotlieb, Olga Feld, Avi Livneh HAREFUAH 2016: 155: November: 637-641.
