Surgical excision of large multinodular goiter using an endoscopic transaxillary approach: a case report.

BACKGROUND: Minimal access surgery for thyroid and parathyroid disease has gained increasing popularity due to excellent endoscopic visualization and overall cosmetic outcome. Most current techniques limit the size of the gland that can be removed to less than 4 cm. Patients with multinodular goiter with gland size greater than 4 cm commonly present for surgical therapy. We evaluated the use of an endoscopic transaxillary approach for the treatment of large multinodular goiters. We herein present a case report of 3 consecutive patients undergoing this technique for benign multinodular goiter disease. METHODS: Three consecutive patients with large multinodular goiter (>6 cm) were treated using a transaxillary endoscopic approach. RESULTS: All patients had successful endoscopic thyroidectomy using a transaxillary endoscopic approach. There were no recurrent nerve injuries. One patient had transient hypoparathyroidism that subsequently resolved after surgery. CONCLUSIONS: Transaxillary endoscopic thyroidectomy may be a viable option to open cervical thyroidectomy in the treatment of patients with large multinodular goiter. We herein present a case report of 3 consecutive patients undergoing this technique for benign multinodular goiter disease.

Endoscopic transaxillary near total thyroidectomy.

BACKGROUND: Since first reported in 1996, endoscopic minimally invasive surgery of the cervical region has been shown to be safe and effective in the treatment of benign thyroid and parathyroid disease. The endoscopic transaxillary technique uses a remote lateral approach to the thyroid gland. Because of the perceived difficulty in accessing the contralateral anatomy of the thyroid gland, this technique has typically been reserved for patients with unilateral disease. OBJECTIVES: The present study examines the safety and feasibility of the transaxillary technique in dissecting and assessment of both thyroid lobes in performing near total thyroidectomy. METHODS: Prior to this study we successfully performed endoscopic transaxillary thyroid lobectomy in 32 patients between August 2003 and August 2005. Technical feasibility in performing total thyroidectomy using this approach was accomplished first utilizing a porcine model followed by three human cadaver models prior to proceeding to human surgery. After IRB approval three female patients with histories of enlarging multinodular goiter were selected to undergo endoscopic near total thyroidectomy. RESULTS: The average operative time for all models was 142 minutes (range 57-327 min). The three patients in this study had clinically enlarging multinodular goiters with an average size of 4 cm. The contralateral recurrent laryngeal nerve and parathyroid glands were identified in all cases. There was no post-operative bleeding, hoarseness or subcutaneous emphysema. CONCLUSION: Endoscopic transaxillary near total thyroidectomy is feasible and can be performed safely in human patients with bilateral thyroid disease.

Early use of recombinant factor VIIa improves mean arterial pressure and may potentially decrease mortality in experimental hemorrhagic shock: a pilot study.

BACKGROUND: Recombinant factor VIIa (rFVIIa) is used for treatment of bleeding episodes in hemophilia patients who develop inhibitors to factors VIII and IX. We tested the hypothesis that administration of rFVIIa early after injury would decrease bleeding and improve survival after experimental hepatic trauma. METHODS: Anesthetized swine were cannulated for blood sampling and hemodynamic monitoring. Avulsion of left median lobe of the liver induced uncontrolled hemorrhage. After a 10% reduction of mean arterial pressure, animals were blindly randomized to receive intravenous rFVIIa (180 microg/kg) (n = 6) or placebo (n = 7). RESULTS: Mortality was 43% (three of seven) in controls versus 0% with rFVIIa (p = 0.08, chi2). Significantly shorter prothrombin time and higher mean arterial pressures were observed in the rFVIIa group. CONCLUSION: Intravenous administration of rFVIIa early after induction of hemorrhage shortens prothrombin time and improves mean arterial pressure. A trend toward improved survival was observed.