RESUMO
The purpose of this study was to examine the interactive effects of alcohol and salience of social cues (personality traits) on allocation of attention in the intoxicated male social drinker. It was expected that inebriated subjects would preferentially attend to high threat relative to low threat information contingent on the information's personal relevance. Seventy-six participants received either alcohol or a placebo, or were in a control condition, and were given the opportunity to attend to personally salient or nonsalient positive, negative, and neutral information. Intoxicated participants viewed negative traits longer than did nonintoxicated subjects and attended to these traits longer in the salient than in the nonsalient condition. Findings are compared to the attention allocation model, and their implications for alcohol-mediated cognitive processes are discussed.
Assuntos
Consumo de Bebidas Alcoólicas/psicologia , Intoxicação Alcoólica/psicologia , Atenção/efeitos dos fármacos , Processos Mentais/efeitos dos fármacos , Meio Social , Adulto , Consumo de Bebidas Alcoólicas/efeitos adversos , Nível de Alerta/efeitos dos fármacos , Conscientização/efeitos dos fármacos , Etanol/efeitos adversos , Etanol/farmacocinética , Humanos , MMPI , Masculino , Autoimagem , Comportamento SocialRESUMO
A number of strains of Oidiodendron truncatum was shown to produce a new antibiotic, PR-1350, which was isolated in the form of an amorphous powder either directly or via a crystalline monomethanolate, PR-1381, which in solution is reconverted to the parent compound. The antibiotic inhibits a broad spectrum of Gram-positive and Gram-negative bacteria in vitro, and has been shown to be active against P-388 lymphocytic leukemia in mice. Biosynthetic considerations based on the results of [1-13C]acetate incorporation indicate that the antibiotic is a diterpene of the clerodane type.