[Prescribers' awareness about the pharmacology of the non-steroidal drugs in the capital town of Antananarivo]. / Connaissance de la pharmacologique des anti-inflammatoires non stéroïdiens par les prescripteurs de la capitale d'Antananarivo.

In order to assess prescribers' level of knowledge about the pharmacology of the non steroidian anti-inflammatory drugs (NSAIDs), we led a prospective study without randomization among the caregivers of three university teaching hospitals and three private hospitals centres of Antananarivo, capital town of Malagasy Republic. The answers to the questionnaire were coded as known or unknown. Statistical analysis (by SPSS 10.0 software for Windows) displayed Fisher's exact test and p value less than 0.05 was set as cut-off for significance. The response rate was 71% (43 over 60), mainly from physicians (62.8%). The correct posology, the non-digestive adverse effects and the adequate follow-up were the main ignored items. Analysis by logistic regression demonstrated association between medical professionals and ignorance of adequate follow-up (p=0.030), female gender and ignorance of the non-digestive adverse effects (p=0.041). In conclusion, routine prescription hides ignorance about the safe use of the drug and periodical recycling of health professionals is helpful.

[Major hypoglycemia during malaria outburst treated by quinine: importance of glucagon]. / Hypoglycémie majeure au cours d'un accés de paludisme traité par la quinine: intérêt du glucagon.

An efficient quinine therapy administered for the treatment of severe malaria has induced a major hypoglycemia in a pregnant woman. Glycemia varied from 0.3 to 0.6 g/l (normal: 0.7-1.1 g/l) despite symptoms correction by infusion of 2.51 of hypertonic glucose serum at 30% per day. The continuous infusion of glucagon: 1 mg diluted in 50 cm3 of physiological saline solution, at 0.5 to 6 ml/h rate has allowed a normal glycemia value and quinine therapy was carried on until the 7th day.