RESUMO
Using morphologic, histochemical, histoenzymatic methods, the authors studied morphogenesis of acetate gastric ulcer in 40 rats subjected to chronic enteral intake of copper-containing pesticide-- copper sulphate. Structural and metabolic basis for perverted regeneration of mucosa near the ulcer under continuous enteral exposure to toxic factor, dose dependence in chronization of acute gastric ulcer were established for the first time.
Assuntos
Mucosa Gástrica/fisiologia , Regeneração , Úlcera Gástrica/patologia , Acetatos/toxicidade , Animais , Doença Crônica , Sulfato de Cobre/toxicidade , Modelos Animais de Doenças , Masculino , Praguicidas/toxicidade , Ratos , Úlcera Gástrica/induzido quimicamente , Úlcera Gástrica/metabolismoRESUMO
Morphological, histochemical, and histoenzymatic studies were employed to study the morphogenetic features of acetate-induced gastric ulcer in 40 rats during chronic enteral administration of the organic chlorine pesticide hexachlorocyclohexane. The authors first established the structural and metabolic bases of mucosal regeneration defects in the region of an ulcer upon chronic enteral exposure to the toxic agent and the dose dependence of the chronic nature of acute gastric ulcer.
