RESUMO
AIM: We introduced routine probiotic supplementation (RPS) of preterm infants in June 2012. We previously reported that RPS reduced the incidence of necrotising enterocolitis (NEC) and mortality in such infants. In this study, we assessed if the benefits of RPS were sustained for infants in the current era. METHOD: We compared the outcomes of preterm infants in recent epoch 3 (RPS, 1st June 2014 to 31st December 2019) versus epoch 2 (RPS, 1st June 2012 to 31st May 2014) and epoch 1 (no RPS, 1st December 2008 to 30th November 2010). Multiple logistic and Cox regression models were used to compare the outcomes. RESULTS: There were 645 infants in epoch 1, 712 in epoch 2 and 1715 in epoch 3. Age at full feeds was significantly lower in epoch 3 vs. 2 and epoch 3 vs. 1 in infants <28 weeks of gestation. NEC and late-onset sepsis (LOS) were significantly lower in epoch 3 vs. 1 in infants <28 weeks. LOS and age at full feeds were significantly lower in epoch 3 vs. 2 and epoch 3 vs. 1 in infants with gestation 28 to 32 weeks. CONCLUSION: The benefits associated with RPS were sustained during epoch 3.
Assuntos
Enterocolite Necrosante , Doenças do Prematuro , Probióticos , Sepse , Lactente , Recém-Nascido , Humanos , Recém-Nascido Prematuro , Probióticos/uso terapêutico , Incidência , Doenças do Prematuro/epidemiologia , Enterocolite Necrosante/epidemiologia , Enterocolite Necrosante/prevenção & controle , Recém-Nascido de muito Baixo PesoRESUMO
We studied the seroprevalence of anti-HAV IgG in children of Bijapur a tier III city/backward district in Karnataka and its relation with sociodemographic parameters. Out of 142 children, 6 months to 15 years who were included, 63 (44.4%) were sero positive, suggesting that Bijapur is a low endemic area.
