1.
Chem Commun (Camb)
; 56(34): 4668-4671, 2020 Apr 30.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32211652
RESUMO
A novel carboxylation radiosynthesis methodology is described starting from cyclotron-produced [11C]CO2 and fluoride-activated silane derivatives. Six carbon-11 labelled carboxylic acids were obtained from their corresponding trimethylsilyl and trialkoxysilyl precursors in a one-pot labelling methodology. The radiochemical yields ranged from 19% to 93% within 12 minutes post [11C]CO2 delivery with a trapping efficiency of 21-89%.