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Eur J Med Chem ; 219: 113378, 2021 Jul 05.
Artigo em Inglês | MEDLINE | ID: mdl-33857729

RESUMO

Biguanides are compounds in which two guanidine moieties are fused to form a highly conjugated system. Biguanides are highly basic and hence they are available as salts mostly hydrochloride salts, these cationic species have been found to exhibit many therapeutic properties. This review covers the research and development carried out on biguanides and accounts the various therapeutic applications of drugs containing biguanide group-such as antimalarial, antidiabetic, antiviral, anticancer, antibacterial, antifungal, anti-tubercular, antifilarial, anti-HIV, as well as other biological activities. The aim of this review is to compile all the medicinal chemistry applications of this class of compounds so as to pave way for the accelerated efforts in finding the drug action mechanisms associated with this class of compounds. Importance has been given to the organic chemistry of these biguanide derivatives also.


Assuntos
Antineoplásicos/química , Biguanidas/química , Anti-Infecciosos/síntese química , Anti-Infecciosos/química , Anti-Infecciosos/uso terapêutico , Antineoplásicos/uso terapêutico , Biguanidas/uso terapêutico , Diabetes Mellitus Tipo 2/tratamento farmacológico , Feminino , Humanos , Hipoglicemiantes/síntese química , Hipoglicemiantes/química , Hipoglicemiantes/uso terapêutico , Metformina/síntese química , Metformina/química , Metformina/uso terapêutico , Síndrome do Ovário Policístico/tratamento farmacológico , Proguanil/síntese química , Proguanil/química , Proguanil/uso terapêutico
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