RESUMO
A Comparative study of three types of measles vaccines was undertaken among 1005 children. Of these 527 were vaccinated with the Serum Institute of India (SII) vaccine, 230 with Schwarz (SC) and 248 were vaccinated with Edmonston-Zegreb (EZ) vaccine (imported from Zegreb). Though the majority of children reacted favourably with all the three vaccines (SII: 98.43%; SC: 93.40%; EZ: 93.0%) with a rise in titre, but the percentage of seroconversion was significantly higher with the SII vaccine (p < 0.01). The Schwarz and Edmonston Zagreb vaccines showed significantly less GM titre as compared with the other age group i.e. 9-12 months (p < 0.05). With Serum Institute of India (SII) vaccine the GM titres were almost similar in the different age groups. The overall GM titre obtained with the SII vaccine was significantly higher than the SC vaccine (p > 0.001) as well as the EZ vaccine (p > 0.001). It is of interest to note that among the infants, 22.5% children had measles antibody in them before vaccination.
PIP: This study compares the efficacy of the three types of measles vaccines undertaken among 1005 children at the General Hospital pediatrics department in Pune, India. Of these children, 527 were vaccinated with the Serum Institute of India (SII) vaccine, 230 with Schwarz (SC), and 258 were vaccinated with Edmonston-Zagreb (EZ) vaccine. Results showed that the percentage of seroconversion was significantly higher with SII vaccine (98.43%) when compared with the SC (93.40%) or the EZ vaccines (93.0%). Majority of the children reacted favorably with the 3 vaccines after the rise in titer. The GM titer in the age group less than 9 months of the Schawarz vaccine was significantly less as compared with 9-12 months. The EZ vaccine also showed significantly less GM titer in the age group less than 9 months compared with the 13-18 month group. The SII vaccine and the GM titer were almost similar in different age groups. The overall GM titer obtained in the SII vaccine was significantly higher than the SC and the EZ vaccines. From this study, a direction to the strategy of measles vaccination was enlightened.
