RESUMO
OBJECTIVES: To evaluate the prognostic significance of tumor volume in computed tomographic (CT) images of non-Hodgkin lymphoma patients. To compare CT volumes with those measured by magnetic resonance imaging (MRI). METHODS: Twenty-five patients with B cell-type non-Hodgkin lymphoma (16 men, 9 women, age range, 48-77 years) were imaged with CT at 5 time points. The volumes and volume reductions were associated with clinical characteristics and treatment outcome. The CT-derived tumor volumes were correlated with MRI volumes derived earlier for the same patients. RESULTS: Good agreement was found between 1-dimensional (1D), 2D, and 3D analyses. The CT-derived median tumor volumes were 306 cm, 174 cm, 75 cm, 28 cm, and 15 cm at the 5 time points. These volumes were found to associate, for example, with mortality and tumor malignancy. The CT-based tumor volumes showed good correlation with MRI. CONCLUSIONS: Tumor volume quantification is a powerful tool that associates with clinical characteristics and treatment outcome.
Assuntos
Linfoma de Células B/diagnóstico por imagem , Linfoma de Células B/patologia , Imageamento por Ressonância Magnética/métodos , Tomografia Computadorizada por Raios X/métodos , Carga Tumoral , Idoso , Meios de Contraste , Feminino , Seguimentos , Humanos , Processamento de Imagem Assistida por Computador/métodos , Imageamento Tridimensional/métodos , Iohexol , Linfoma de Células B/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Intensificação de Imagem Radiográfica/métodos , Reprodutibilidade dos Testes , Análise de Sobrevida , Resultado do TratamentoRESUMO
OBJECTIVE: The aim of this study was to determine the volume of non-Hodgkin lymphomas (NHLs) using semiautomatic segmentation and to correlate these results with clinical findings, treatment, and prognosis in patients with B-cell-type NHL. METHODS: For this study, 29 patients with NHL underwent magnetic resonance imaging at 5 time points after onset of disease. Volumetric analysis of the tumors was accomplished with semiautomatic segmentation by the Anatomatic software. RESULTS: The median tumor volumes from the first to the fifth examination were 468, 256, 90, 38, and 33 cm. Good correlation with 1-dimensional and 2-dimensional measures, used as standard methods in response categorization, was found. Surprisingly, volume reductions in excess of 239 cm after only 1 week of chemotherapy decreased the survival probability. CONCLUSIONS: Volume measurements seem to be highly informative for prognosis in the very early stages of treatment for patients with NHL.
