RESUMO
A novel family of water-soluble π-conjugated hexaazatrinaphthylenes-based dendritic architectures constructed by hexaketocyclohexane and 1,2,4,5-benzenetetramine units is developed in a microwave-assisted organic synthesis (MAOS) approach. The structures and purity of these compounds are verified by 1H and 13C-NMR, MALDI-TOF MS, UV-vis, elemental analysis, DSC, AFM, STM and cyclic voltammetry.
Assuntos
Dendrímeros/química , Dendrímeros/síntese química , Micro-Ondas , Naftalenos/química , Naftalenos/síntese químicaRESUMO
Two new dammarane triterpenes have been isolated from the stem bark exudates of Maytenus macrocarpa. Their structures were determined by extensive 1D and 2D NMR spectroscopic studies as 24(Z)-3-oxodammara-20(21),24-dien-27-oic acid (1) and octa-nor-13-hydroxydammara-1-en-3,17-dione (2). These compounds were tested for antitumoral activity.
Assuntos
Maytenus/química , Triterpenos/química , DNA de Plantas/química , DNA de Plantas/genética , Espectroscopia de Ressonância Magnética , Saccharomyces cerevisiae/metabolismo , Espectrofotometria Infravermelho , Espectrofotometria Ultravioleta , Triterpenos/isolamento & purificação , DamaranosRESUMO
The resinous exudate of Baccharis grisebachii which is used to treat ulcers, burns, and skin sores in Argentina showed activity towards dermatophytes and bacteria. Two diterpenes, eight p-coumaric acid derivatives, and two flavones were isolated from the exudate and the structures elucidated by spectroscopic methods. 3-Prenyl-p-coumaric acid and 3,5-diprenyl-p-coumaric acid were active towards Epidermophyton floccosum and Trichophyton rubrum with MICs of 50 and 100-125 microg/ml, respectively. The diterpene labda-7,13E-dien-2beta,15-diol was active towards Epidermophyton floccosum and Trichophyton rubrum with MICs of 12.5 microg/ml while the MIC against Microsporum canis and Trichophyton mentagrophytes was 25 microg/ml. The diterpene was also active towards Microsporum gypseum with a MIC of 50 microg/ml, and showed inhibition in both Staphylococcus aureus (methicilline resistant and sensible strains) with MICs of 125 microg/ml. The results support the use of Baccharis grisebachii in Argentinian traditional medicine.
Assuntos
Antibacterianos/farmacologia , Antifúngicos/farmacologia , Baccharis , Resinas Vegetais/farmacologia , Antibacterianos/química , Antibacterianos/isolamento & purificação , Antifúngicos/química , Antifúngicos/isolamento & purificação , Argentina , Bactérias/efeitos dos fármacos , Ácidos Cumáricos/química , Ácidos Cumáricos/isolamento & purificação , Ácidos Cumáricos/farmacologia , Diterpenos/química , Diterpenos/isolamento & purificação , Diterpenos/farmacologia , Flavonoides/química , Flavonoides/isolamento & purificação , Flavonoides/farmacocinética , Fungos/efeitos dos fármacos , Medicina Tradicional , Componentes Aéreos da Planta , Resinas Vegetais/química , Resinas Vegetais/isolamento & purificaçãoRESUMO
A new sesquiterpene evoninate alkaloid (1), and two sesquiterpenes (2, 3) with a dihydro-beta-agarofuran skeleton, along with three known sesquiterpenes (4-6), were isolated from the seeds of Euonymus europaeus. Their structures were elucidated by high resolution mass analysis, and one- and two-dimensional (1D and 2D) NMR spectroscopy, including homonuclear and heteronuclear correlation [correlation spectroscopy (COSY), rotating frame Overhauser enhancement spectroscopy (ROESY), heteronuclear single quantum coherence (HSQC), and heteronuclear multiple bond correlation (HMBC)] experiments.
