Influence of strontium containing fluorophosphate glass onto structural and mechanical behavior of MTA network.

OBJECTIVE: This study aimed to evaluate the effect of incorporation of strontium based fluoro phosphate glass (SrFPG) 48P2O5-29CaO-14NaO-3CaF2-6SrO on physico chemical and biological properties of mineral trioxide aggregate (MTA). METHODS: Optimized SrFPG glass powder were prepared using planetary ball mill and incorporated into MTA in varying proportion (1, 5, 10 wt%) to obtain SrMT1, SrMT5, SrMT10 bio-composite respectively. The bio-composites were characterized using XRD, FTIR and SEM-EDAX before and after soaking for 28 days in stimulated body fluid (SBF) solution. To assess the mechanical properties and biocompatibility of the prepared bio-composite, density, pH analysis, compressive strength and cytotoxicity evaluation using MTT assay were done before and after soaking for 28 days in SBF solution. RESULTS: A nonlinear variation in compressive strength and pH values was noted. Of the bio-composites, SrMT10 was evidenced with rich apatite formation in XRD, FTIR and SEM with EDAX analysis. MTT assay showed increased cell viability in all the samples before and after in vitro studies.

Recent Development of Heat and Mass Transport in the Presence of Hall, Ion Slip and Thermo Diffusion in Radiative Second Grade Material: Application of Micromachines.

This article describes the incompressible two-dimensional heat and mass transfer of an electrically conducting second-grade fluid flow in a porous medium with Hall and ion slip effects, diffusion thermal effects, and radiation absorption effects. It is assumed that the fluid is a gray, absorbing-emitting but non-scattering medium and the Rosseland approximation is used to describe the radiative heat flux in the energy equation. It is assumed that the liquid is opaque and absorbs and emits radiation in a manner that does not result in scattering. It is considered an unsteady laminar MHD convective rotating flow of heat-producing or absorbing second-grade fluid across a semi-infinite vertical moving permeable surface. The profiles of velocity components, temperature distribution, and concentration are studied to apply the regular perturbation technique. These profiles are shown as graphs for various fluid and geometric parameters such as Hall and ion slip parameters, radiation absorption, diffusion thermo, Prandtl number, Schmidt number, and chemical reaction rate. On the other hand, the skin friction coefficient and the Nusselt number are determined by numerical evaluation and provided in tables. These tables are then analysed and debated for various values of the flow parameters that regulate it. It may be deduced that an increase in the parameters of radiation absorption, Hall, and ion slip over the fluid region increases the velocity produced. The resulting momentum continually grows to a very high level, with contributions from the thermal and solutal buoyancy forces. The temperature distribution may be more concentrated by raising both the heat source parameter and the quantity of radiation. When one of the parameters for the chemical reaction is increased, the whole fluid area will experience a fall in concentration. Skin friction may be decreased by manipulating the rotation parameter, but the Hall effect and ion slip effect can worsen it. When the parameter for the chemical reaction increases, there is a concomitant rise in the mass transfer rate.

Synthesis of novel ethyl 2,4-disubstituted 8-(trifluoromethyl)pyrido[2',3':3,4]pyrazolo[1,5-a]pyrimidine-9-carboxylate derivatives as promising anticancer agents.

A series of novel pyrido[2',3':3,4] pyrazolo[1,5-a]pyrimidine derivatives 6-9 were prepared in single step starting from 3-amino-6-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate 5 on reaction with symmetrical and unsymmetrical aliphatic and aromatic 1,3-diketones/α,ß unsaturated ketones/α,ß unsaturated keto ethers under conventional method. All the final compounds 6a-c, 8a-b and 9a-l were screened for anticancer activity against five human cancer cell lines such as PC-3 (CRL-1435), MDA-MB-231 (HTB-26), Hep G2 (HB-8065), HeLa (CCL-2) and normal HUVEC (CRL-1730). Compounds 8a, 9f and 9k which showed promising anticancer activity have been identified. Further, the promising compounds (8a and 9f) were able to inhibit the human topoisomerase I (TopI) activity similar to that of camptothecin.

A retrospective analysis of osteochondroma of scapula following excision biopsy.

Scapula is an uncommon site for osteochondroma. There is a paucity of information regarding postoperative complications, recurrence of osteochondroma, functional improvement. A retrospective analysis of 9 patients treated for osteochondroma scapula over a period of 4 years was undertaken to assess postoperative complications, recurrence, and functional improvement following excision biopsy for osteochondroma scapula. All patients of any age group who were diagnosed with osteochondroma scapula and treated with excision biopsy in the past 6 years were included in the study. Patients were followed up for recurrence, postoperative complications and functional assessment using modified UCLA shoulder rating scale. The mean age at presentation was 13.7 years. Boys were more commonly affected than girls with a male to female ratio of 7:2. There was no incidence of recurrence of osteochondroma, postoperative wound complications or functional limitation following excision biopsy of osteochondroma scapula. We conclude that preoperative functional restriction in osteochondroma of scapula is mainly due to location of tumour especially when present over ventral or ventromedial aspect scapula. After complete excision they do not cause any functional limitations.

(Z)-2-(2-Hy-droxy-4-meth-oxy-benzyl-idene)-1-benzofuran-3(2H)-one.

In the title compound, C(16)H(12)O(4), the 1-benzofuran-one unit is in a planar conformation [C-C-C-C = 179.69 (12)°]. The conformation around the C=C double bond [1.3370 (17) Å] is Z. In the crystal, the mol-ecules are stabilized by O-H⋯O (running parallel to the bc plane) and C-H⋯O hydrogen bonds.

Correlation of "in vitro" release and "in vivo" absorption characteristics of rifampicin from ethylcellulose coated nonpareil beads.

The purpose of this study was to investigate the possibility to develop different levels of correlation between in vitro dissolution parameters and in vivo pharmacokinetic parameters for three rifampicin formulations. A level A correlation of in vitro release and in vivo absorption could be obtained for individual plasma level data by means of the Wagner and Nelson method. Linear correlation could be obtained when percent dose released in vitro was plotted vs percent dose absorbed in vivo with correlation coefficients between 0.954,0.983 and 0.997 for the formulations studied. A second level correlation between mean in vitro dissolution time (MDT) and mean in vivo residence time (MRT) was performed with a correlation coefficient of 0.536,0.420 and 0.335. Finally, it was also possible to establish a good in vitro-in vivo correlation when the T(50%hrs) (time taken to release 50% of rifampicin) in vitro and C(max),T(max) or AUC in vivo were compared.