[Somatosensory evoked potentials in the sleep-wakefulness cycle in healthy subjects and narcolepsy patients]. / Somatosensornye vyzvannye potentialy v tsikle son--bodrstvovanie u zdorovykh ispytuemykh i bol'nykh narkolepsiei.

Studies of somatosensory evoked potentials (SSEPs) were conducted in various functional states of sleep-alertness cycle (relaxed alertness, 2-nd and delta-stages of slow sleep, rapid sleep) in 7 healthy subjects and 8 patients with polysymptom narcolepsy. Integrated amplitude (IA) was calculated in poststimulus intervals, accordingly to SSEPs division into groups of early (20-80 ms), mean (80-200 ms) and late (200-400 ms) components. It has been shown that in patients with polysymptom narcolepsy IA of all SSEPs components in alertness was lower than in healthy subjects; during sleep higher IA values of earlier components were found in comparison with healthy subjects and lower values--of later negative wave at slow sleep. Psychophysiological interpretation of high amplitude negative shift in the area of late SSEPs components during slow sleep is suggested.

[Clinico-electrophysiologic research on narcolepsy (an evolutionary-dissolution approach)]. / Kliniko-élektrofiziologicheskoe issledovanie narkolepsii (évoliutsionno-dissoliutsionnyi podkhod).

The results of clinical and polygraphic investigation of sleep and wakefulness using spectral analysis and fast Fourier transform of EEG are presented with the data on somatosensory evoked potentials in different brain states of multiply symptomatic narcoleptic patients. Functional insufficiency of thalamocortical unspecific system was revealed. The brainstem-hypothalamic systems of sleep-wakefulness cycle regulation were activated. Evolutional approach was applied to the issues of sleep-wakefulness cycle pathology. The possibility of reflection of evolutional regularities of sleep-wakefulness cycle in multiply symptomatic narcolepsy is discussed.