Associations between SARS-CoV-2 RNA concentrations in wastewater and COVID-19 rates in days after sampling in small urban areas of Seville: A time series study.

Wastewater surveillance systems for SARS-CoV-2 can be used to support public health decisions, complementary to clinical surveillance. We examined the lead-lag associations between SARS-CoV-2 RNA copies in wastewater and COVID-19 rates in relatively small urban areas of Seville, adjusting for internal mobility, temperature, and wastewater-related variables. The association COVID-19 rates-RNA copies were statistically significant from three to 27 days after sampling. Temperature is a confounding factor for both viral RNA counts and mobility. The model that best fitted data used cases six days after sampling. A logarithmic unit increase in viral RNA count in wastewater was associated with a 26.9% increase in COVID-19 rate per 100,000 inhabitants (95% CI: 13.1-42.4%), within the urban area, six days later. Surveillance system for SARS-CoV-2 in wastewater has great potential for public health. Knowing the specific association between SARS-CoV-2 RNA copies in wastewater and COVID-19 daily rates may help to improve its performance.

Static Magnetic Field Stimulation over the Visual Cortex Increases Alpha Oscillations and Slows Visual Search in Humans.

Transcranial static magnetic field stimulation (tSMS) was recently introduced as a promising tool to modulate human cerebral excitability in a noninvasive and portable way. However, a demonstration that static magnetic fields can influence human brain activity and behavior is currently lacking, despite evidence that static magnetic fields interfere with neuronal function in animals. Here we show that transcranial application of a static magnetic field (120-200 mT at 2-3 cm from the magnet surface) over the human occiput produces a focal increase in the power of alpha oscillations in underlying cortex. Critically, this neurophysiological effect of tSMS is paralleled by slowed performance in a visual search task, selectively for the most difficult target detection trials. The typical relationship between prestimulus alpha power over posterior cortical areas and reaction time (RT) to targets during tSMS is altered such that tSMS-dependent increases in alpha power are associated with longer RTs for difficult, but not easy, target detection trials. Our results directly demonstrate that a powerful magnet placed on the scalp modulates normal brain activity and induces behavioral changes in humans.

Complicaciones graves en reconstrucción mamaria. Colgajo de músculo dorsal ancho, una técnica útil y necesaria / Severe complications in breast reconstruction. Latissimus dorsi flap is a useful and necessary technique

Introducción. La reconstrucción mamaria (RM) es un procedimiento en claro aumento y debe ser una opción estándar en el tratamiento integral del cáncer de mama. La elección de la técnica de RM debe ser individualizada para cada paciente, según riesgo, presencia de contraindicaciones y preferencias. El colgajo de músculo dorsal ancho (CMDA), por no ser un método estrictamente autólogo y de mayor complejidad que la expansión-prótesis, es generalmente una elección secundaria. Sin embargo, es la técnica de elección para solucionar complicaciones graves de otros métodos (extrusión de prótesis o necrosis) Pacientes. Presentamos 6 pacientes de nuestro programa de RM en las que el CMDA ha sido la técnica que permitió solucionar complicaciones graves, como necrosis total de un colgajo de músculo recto anterior del abdomen (TRAM), extrusión de prótesis y radiodermitis ulcerada. Conclusión. Consideramos que el CMDA es una técnica muy útil y necesaria en un programa de RM. En complicaciones graves de otras técnicas de RM y en las pacientes con radioterapia es la técnica de elección (AU)