Comparing the influence of cuspal angulation, occlusal loading, and connector widths between tooth- and implant-supported zirconia fixed dental prosthesis.

Background: Few studies have established the relationship between connector widths, cuspal angulation, loading forces, and supporting structures of zirconia fixed dental prosthesis (FDP). The objective of the study was to compare the stress distribution in implant- and tooth-supported zirconia FDP with different connector designs, and cuspal angulations of replaced teeth under diverse angulations of forces. Methods: Finite element (FE) analysis was done by simulating a 3-unit implant- and tooth-supported FDP. FE models with varying cuspal angulations 0°, 20°, and 33° and connector designs 2 mm, 2.5 mm, and 3 mm was generated. The simulated models were loaded with 100 N of forces under different axial and non-axial angulations. The graphical and numerical stresses were observed, recorded, and statistically analyzed. Results: Higher stress of 245.55 MPa in implant-supported FDP and lower stress value of 28.22 MPa in tooth-supported FDP was observed at 0-cuspal inclination for 3 mm connector width. The data were statistically analyzed with unpaired t test to eliminate the differences. The inter-group, intra-group tests, p and t values for various connector, and tooth angulations of tooth- and implant-supported FDP were statistically insignificant. (p > 0.05). Conclusion: There was no statistically significant difference in stress was observed between tooth- and implant-supported FDP for different connector widths, cuspal inclination, and diverse angulation of forces.

Toxicological effect of endocrine disrupting insecticide (deltamethrin) on enzymatical, haematological and histopathological changes in the freshwater iridescent shark, Pangasius hypothalamus.

This study investigated the deltamethrin (DMN) induced harmful effects on Pangasius hypophthalmus using enzymatic activity, haematological, and histopathological changes. LC50 value was 0.021 mg/L at 96 h, and sublethal toxicity was tested for 45 days at two `concentrations (i.e., 1/5th and 1/10th of LC50). Haematological parameters and enzymatic activities significantly changed between DMN-exposed and control groups (p < 0.05). Histopathologically, both DMN doses induced liver hyperemia, hepatic cell rupture, necrosis, hypertrepheoid bile duct, shifting nuclei, vascular haemorrhage, and hepatocyte degeneration, while in gill, secondary lamellae destruction, a fusion of adjacent gill lamellae, hypertrophy, hyperplasia, adhesion, and fusion were noticed. Kidney developed melanomacrophages, increased periglomerular and peritubular space, vacuolation, decreased glomerulus, hyaline droplets in tubular cells, loss of tubular epithelium, distal convoluted segment hypertrophy, and granular layer in brain pyramid and Purkinje cell nucleus. But, limiting pesticide impacts on freshwater fish and their habitat requires a holistic, cradle-to-grave approach and toxicological studies.