Maternal adropin levels in patients with gestational diabetes mellitus: a systematic review and meta-analysis.

BACKGROUND: Adropin is a regulatory protein with potential implications in energy homeostasis, glucose regulation, and insulin resistance. AIM: The aim of this meta-analysis was to compare the maternal serum/plasma adropin levels between gestational diabetes mellitus (GDM) patients and non-GDM controls. METHODS: Relevant studies were retrieved by online database and manual searching. The standardized mean differences (SMDs) with 95% confidence intervals (CIs) were obtained by a random-effects meta-analysis. A one-study leave-out sensitivity analysis and trimester-wise subgroup analysis were performed. RESULTS: A total of eight observations were included in this meta-analysis. The results based on random-effects meta-analysis indicated that adropin levels were significantly increased in GDM patients as compared to non-GDM controls (SMD = 2.41, 95% CI = 0.52-4.29, p= .01). The sensitivity analysis indicated that no single study had significantly influenced the overall outcome. CONCLUSIONS: The results indicate that maternal serum/plasma adropin concentrations were significantly higher in GDM patients as compared to non-GDM controls suggesting the potential associations of adropin in GDM. Despite this, further studies are needed to investigate the mechanistic, diagnostic and prognostic roles of trimester-wise adropin levels in GDM and associated fetal outcomes.

Adropin levels and its associations as a fat-burning hormone in patients with polycystic ovary syndrome: a correlational meta-analysis.

AIMS: Adropin is a peptide hormone with potential implications in patients with polycystic ovary syndrome (PCOS). The aim of this meta-analysis was to compare the circulating (serum/plasma) and follicular fluid adropin levels between human PCOS patients and non-PCOS controls. METHODS: Relevant studies were retrieved by online database and manual searching. The standardized mean differences (SMDs) with 95% confidence intervals (CIs) were obtained by a random-effects meta-analysis. Meta-analysis of correlations was performed for the associations of adropin with anthropometric, lipid, insulin resistance and hormonal covariates. The funnel plot analysis with Begg's and Egger's tests was used for publication bias. RESULTS: A total of 9 studies were included in this meta-analysis. The results indicated that the adropin levels were significantly decreased in PCOS patients as compared to non-PCOS controls (SMD = -1.87, 95% CI = -2.55 to -1.18, p < .0001). This decrease was more evident in overweight PCOS patients than their normoweight counterparts (SMD = -0.55, 95% CI = -0.80 to -0.30, p < .0001). A one-study leave-out sensitivity analysis indicated that no single study had a significant influence on the overall outcome, suggesting the robustness of this meta-analysis. There were significant associations of decreased adropin levels with the body mass index, dyslipidemia and insulin resistance in PCOS. CONCLUSION: Adropin levels are significantly reduced in PCOS patients compared to controls, and this decrease was more evident in overweight PCOS patients.

A study on knowledge, attitude and practice regarding voluntary blood donation among medical students in Puducherry, India.

Knowledge, attitude and practice studies have been used to understand the various factors that influence blood donation which is the basis for donor mobilization and retention strategies. Role of youngsters in voluntary blood donation is crucial to meet the demand of safe blood. The present study was aimed to assess the level of knowledge, attitude and practice regarding voluntary blood donation among the health care students. A validated and pre-tested questionnaire on knowledge, attitude and practice on blood donation were assessed among 371 medical students from Sri Lakshmi Narayana Institute of Medical Sciences and Research Institute, Puducherry, India. Result showed that knowledge on blood donation among respondents was 44.8% (1st year 36.7%, 2nd year 42.8% and 3rd year 54.9%). About 62.6% of non-donors (1st year 51%, 2nd year 61% and 3rd year 77%) showed positive attitude by expressing their willingness to donate blood while 22.8%.of the non-donors had negative attitude (1st year 33%, 2nd year 23% and 3rd year 13%). In practice 13.2% of students had donated blood (1st year 10%, 2nd year 13% and 3rd year 24%), in which 2.7% of male students alone donating blood on regular basis. Over all 3rd year student showed significantly higher knowledge compared with 1st years, in attitude and practice section 3rd year student's showed significantly higher positive attitude and practice than that of 1st and 2nd years. The present study reveals that there is a positive association among knowledge, attitude and practice on blood donation, which suggest that positive attitude and practice can be improved by inculcating knowledge on blood donation among college students to recruit and donate blood regularly, which will help to achieve 100% of blood donation on voluntary basis.

Effect of reuse of polysulfone membrane on oxidative stress during hemodialysis.

Patients with chronic renal failure, especially those on long-term hemodialysis (HD), have a high incidence of premature cardiovascular disease. Oxidative stress, which occurs when there is an excessive free radical production or low antioxidant level, has recently been implicated as a causative factor in atherogenesis. Hourly changes in malondialdehyde (MDA) and antioxidant enzymes, vitamins, lipid profile and ferric reducing ability of plasma (FRAP) were studied with the first use and immediate subsequent reuse of polysulfone dialysis membrane in 27 patients on regular HD treatment. Data were corrected for hemoconcentration and standardized to measure the rate of change. Increase in MDA and erythrocyte catalase along with decrease in plasma vitamin E and FRAP levels and no change in glutathione peroxidase levels were observed as a result of both fresh and reuse dialysis. These findings indicate a net oxidative stress in both fresh as well as dialyzer reuse sessions. There was no significant change in oxidative stress in both fresh and reuse sessions. The oxidative stress with reuse dialysis was less when compared to first use dialysis, but the difference was not statistically significant.