Mitochondrial Uncoupling Protein 2 (UCP2) Regulates Retinal Ganglion Cell Number and Survival.

In the brain, mitochondrial uncoupling protein 2 (UCP2) has emerged as a stress signal associated with neuronal survival. In the retina, UCP2 is expressed primarily by retinal ganglion cells. Here, we investigated the functional relevance of UCP2 in the mouse retina. Increased expression of UCP2 significantly reduced apoptosis during the critical developmental period resulting in elevated numbers of retinal ganglion cells in the adult. Elevated UCP2 levels also protected against excitotoxic cell death induced by intraocular injection of either NMDA or kainic acid. In monolayer cultures of retinal cells, elevated UCP2 levels increased cell survival and rendered the cells independent of the survival-promoting effects of the neurotrophic factors BDNF and CNTF. Taken together, these data implicate UCP2 as an important regulator of retinal neuron survival both during development and in adult animals.

Radiographic localization of mental foramen in Northeast and South Indian ethnic groups of Indian population.

BACKGROUND AND OBJECTIVES: The position of mental foramen varies in different ethnic groups. The position of mental foramen is mainly important for achieving effective mental nerve block to carry out dental surgical procedures in mandible. Deviation in its position can be a cause of complication during local anesthesia or surgical procedures. The position of the mental foramen in South Indian and Northeast Indian population has not been reported. The purpose of the current study was to determine the most common location of the mental foramen (MF) and its bilateral symmetry in selected Indian population. MATERIALS AND METHODS: 380 digital panoramic radiographs (DPR) of a randomly selected 2 Ethnic groups of Indian population were studied. RESULTS: The common position (59.2%) of the mental foramen was located between the 1st and 2nd premolars (P3) in Northeast Indians and in South Indians the common location (62.8%) was in line with the long axis of the 2nd premolar (P4), which was statistically significant in both Populations. CONCLUSION: A bilateral symmetry was observed in the location of mental foramina, either mesial to or in line with the long axis of the 2nd premolar, which is consistent with the observations of similar studies in various ethnic or racial groups. In our study a statistically significant association between the 2 ethnic groups and the position of mental foramen exists. Therefore the position of mental foramen may be specific to racial groups facilitating accurate landmark for mental nerve block depending on the ethnic group. Further, studies are required with larger sample for better understanding of mental foramen location in different ethnic groups.