Anatomy of the Brachycephalic Canine Hard Palate and Treatment of Acquired Palatitis Using CO2 Laser.

The goal of this article is to review the anatomy of the brachycephalic canine hard palate and provide a step-by-step guide on diagnosis and treatment of acquired palatitis using the CO2 surgical laser. Brachycephalic breed-related defects are not only limited to the upper airways, some dogs may develop secondary systemic or localized problems. An abnormality that is over-represented in some breeds such as boxers and bulldogs is prominent palatal rugae. The greater depth of the palatal rugae allows for the entrapment of plaque, food debris and hair. Thus, acquired palatitis or granulomatous lesions may develop. This oral pathology and its consequences are commonly neglected by the owners and frequently missed by the veterinarians. Scientific evidence-based diagnosis and treatment for this breed-related oral pathology are absent in the veterinary literature. This article is the first in providing the elements needed for an adequate morphological characterization of the canine hard palate, allowing veterinarians to appropriately identify anomalous areas of the soft tissue component of the hard palate. This article illustrates the use of a noninvasive surgical technique to prevent and cure the sequelae associated with anomalous palatal rugae. The CO2 surgical laser provides a suitable method by offering the fast resolution of the lesions and permanent results.

Malignant Transformation of a Canine Papillomavirus Type 1-Induced Persistent Oral Papilloma in a 3-Year-Old Dog.

This case report describes a rare case of a persistent canine papillomavirus type 1 (CPV-1)-induced oral papilloma that underwent malignant transformation into an oral squamous cell carcinoma (OSCC) in a 3-year-old Labrador retriever cross. Initially, the patient had multiple and multifocal verrucous lesions populating the oral cavity exclusively. The papillomas persisted despite multiple surgical ablations, azithromycin, interferon α-2b, alternative medicines, and off-label drug use of an immunostimulant. After 1 year and 6 months, an aggressive lesion developed at the level of the left mandibular first molar (309) and progressed to a well-differentiated invasive OSCC. The presence of CPV-1 DNA in the OSCC, and the known oncogenic abilities of CPV-1, suggests that this virus might have played a significant role in the emergence of the OSCC that ultimately led to the patient's euthanasia due to poor quality of life. This is the first well-documented case where OSCC has developed from an oral papilloma caused by CPV-1 in which the presence of coinfection by another papillomavirus was excluded by multiple polymerase chain reaction tests using various primers.