1.
Angew Chem Int Ed Engl
; 50(52): 12534-7, 2011 Dec 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22095645
RESUMO
Sweet screens: A high-throughput screening platform for identification of inhibitors of sialyl- and fucosyltransferases based on fluorescence polarization (FP) has been developed. An analogue of the natural donor substrate carrying a fluorescent label (green star) is transferred to a glycoprotein acceptor, which results in robust FP. The screening of 16,000 compounds against different glycosyltransferases has identified various interesting inhibitors.