Autobiographical Narratives and Research on the Constitution of Subjectivity in the Vygostkian Perspective / Narrativas Autobiográficas y la Investigación sobre la Constitución de la Subjetividad en la Perspectiva Vygostkiana / Narrativas Autobiográficas e a Pesquisa da Constituição da Subjetividade na Perspectiva Vigostkiana

Abstract Research on the constitution of subjectivity continues to be a relevant topic for Psychology. This study aimed to analyze the relevance of exploring autobiographical narratives as a methodological resource for understanding this process. Anchored in the premises of historical-cultural psychology in dialogue with other theoretical perspectives, the defended thesis is that, through this theoretical-methodological alternative, it is possible to investigate the different interrelated domains in the processes of constitution of subjectivities, such as the works of memory, language and the dynamic character that they establish with historical and cultural circumstances. The text comprises four parts: the first explores the challenges involved in researching subjectivity; the second, the contributions of Vygotskian psychology to the understanding of the phenomenon; the third, the fecundity of narratives as methodological resources for the study of subjectivation processes. In the last topic, considerations are made about some results of research carried out from school memories.

Resumo A pesquisa sobre a constituição da subjetividade continua sendo um tema relevante para a Psicologia. Este estudo objetivou analisar a pertinência da exploração das narrativas autobiográficas como recurso metodológico para a compreeensão de tal processo. A tese defendida, ancorada nas premissas da psicologia histórico-cultural em diálogo com outras perspectivas teóricas, é que, por meio dessa alternativa teórico-metodológica, é possível investigar os diferentes domínios inter-relacionados nos processos de constituição das subjetividades, como os trabalhos da memória, da linguagem e o caráter dinâmico que estabelecem com as circunstâncias históricas e culturais. Quatro partes compõem o texto: a primeira explora os desafios envolvidos na pesquisa sobre a subjetividade; a segunda, as contribuições da psicologia vygotskiana para a compreensão do fenômeno; a terceira, a fecundidade das narrativas como recursos metodológicos para o estudo dos processos de subjetivação; no último tópico, são feitas considerações sobre alguns resultados de pesquisas realizadas a partir das memórias escolares.

Resumen La investigación sobre la constitución de la subjetividad continúa siendo un tema relevante para la Psicología. Este estudio tuvo como objetivo analizar la pertinencia de explorar las narrativas autobiográficas como recurso metodológico para la comprensión de este proceso. La tesis defendida, anclada en los presupuestos de la psicología histórico-cultural en diálogo con otras perspectivas teóricas, es que, a través de esta alternativa teórico-metodológica, es posible investigar los diferentes dominios interrelacionados en los procesos de constitución de las subjetividades, como el obras de memoria, lenguaje y el carácter dinámico que establecen con las circunstancias históricas y culturales. Cuatro partes componen el texto: la primera explora los desafíos que implica investigar la subjetividad; el segundo, los aportes de la psicología vygotskiana a la comprensión del fenómeno; el tercero, la fecundidad de las narrativas como recursos metodológicos para el estudio de los procesos de subjetivación; en el último tema, se hacen consideraciones sobre algunos resultados de investigaciones realizadas a partir de las memorias escolares.

Congenital hyperinsulinism in two siblings with ABCC8 mutation: same genotype, different phenotypes.

Congenital hyperinsulinism (CHI) is a heterogenous disease caused by insulin secretion regulatory defects, being ABCC8/KCNJ11 the most commonly affected genes. Therapeutic options include diazoxide, somatostatin analogues and surgery, which is curative in focal CHI. We report the case of two siblings (born two years apart) that presented themselves with hypoketotic hyperinsulinemic persistent hypoglycemias during neonatal period. The diagnosis of diffuse CHI due to an ABCC8 compound mutation (c.3576delG and c.742C>T) was concluded. They did not benefit from diazoxide therapy (or pancreatectomy performed in patient number 1) yet responded to somatostatin analogues. Patient number 1 developed various neurological deficits (including epilepsy), however patient number 2 experienced an entirely normal neurodevelopment. We believe this case shows how previous knowledge of the firstborn sibling's disease contributed to a better and timelier medical care in patient number 2, which could potentially explain her better neurological outcome despite their same genotype.

Congenital hyperinsulinism in two siblings with ABCC8 mutation: same genotype, different phenotypes

SUMMARY Congenital hyperinsulinism (CHI) is a heterogenous disease caused by insulin secretion regulatory defects, being ABCC8/KCNJ11 the most commonly affected genes. Therapeutic options include diazoxide, somatostatin analogues and surgery, which is curative in focal CHI. We report the case of two siblings (born two years apart) that presented themselves with hypoketotic hyperinsulinemic persistent hypoglycemias during neonatal period. The diagnosis of diffuse CHI due to an ABCC8 compound mutation (c.3576delG and c.742C>T) was concluded. They did not benefit from diazoxide therapy (or pancreatectomy performed in patient number 1) yet responded to somatostatin analogues. Patient number 1 developed various neurological deficits (including epilepsy), however patient number 2 experienced an entirely normal neurodevelopment. We believe this case shows how previous knowledge of the firstborn sibling's disease contributed to a better and timelier medical care in patient number 2, which could potentially explain her better neurological outcome despite their same genotype.