RESUMO
Los antiinflamatorios no esteroides son la segunda causa de reacciones a medicamentos después de los beta-lactámicos. La prevalencia de las reacciones a antiinflamatorios no esteroideos en la población general es de 0,1% a 0,3% y la prevalencia de anafilaxia inducida por ellos es de 0,01%. La intolerancia al ácido acetilsalicílico o a los antiinflamatorios no esteroides se presenta con síntomas como urticaria aguda, angioedema, crisis asmática, enfermedad respiratoria exacerbada por ácido acetilsalicílico y anafilaxia. Presentamos una revisión actualizada basada en tres casos de pacientes con intolerancia al ácido acetilsalicílico o a los antiinflamatorios no esteroideos que, por sus enfermedades concomitantes, requerían tratamiento permanente conácido acetilsalicílico. Después de someterlos a un protocolo de desensibilización rápida ácido acetilsalicílico en una unidad de cuidados intensivos, estos pacientes pudieron continuar recibiendo ácido acetilsalicílico diariamente sin efectos adversos.
Adverse reactions to nonsteroidal antinflammatory drugs are the second cause of reactions to drugs after beta-lactams. Prevalence of these reactions among general population is between 0.1-0.3%, and prevalence of nonsteroidal antinflammatory drug-induced anaphylaxis is 0.01%. Acetylsalicylic acid or nonsteroidal antinflammatory drug sensitivity can be manifested as acute urticaria, angioedema, acute asthma, acetylsalicylic acid exacerbated respiratory disease and anaphylaxis. An updated review based on three cases of patientes with acetylsalicylic acid or nonsteroidal antinflammatory drug intolerance is presented in which, because of their concomitant diseases, permanent treatment with acetylsalicylic acid was required. After undergoing a fast acetylsalicylic acid desentization protocol in an intensive care unit, these patients were able to receive daily acetylsalicylic acid doses without any adverse effects.
Assuntos
Anafilaxia , Anti-Inflamatórios não Esteroides , Aspirina , Asma , Dessensibilização Imunológica , Pólipos Nasais , SinusiteRESUMO
Adverse reactions to nonsteroidal antinflammatory drugs are the second cause of reactions to drugs after beta-lactams. Prevalence of these reactions among general population is between 0.1-0.3%, and prevalence of nonsteroidal antinflammatory drug-induced anaphylaxis is 0.01%. Acetylsalicylic acid or nonsteroidal antinflammatory drug sensitivity can be manifested as acute urticaria, angioedema, acute asthma, acetylsalicylic acid exacerbated respiratory disease and anaphylaxis. An updated review based on three cases of patientes with acetylsalicylic acid or nonsteroidal antinflammatory drug intolerance is presented in which, because of their concomitant diseases, permanent treatment with acetylsalicylic acid was required. After undergoing a fast acetylsalicylic acid desentization protocol in an intensive care unit, these patients were able to receive daily acetylsalicylic acid doses without any adverse effects.
