Process based simulation of tree growth and ecosystem services of urban trees under present and future climate conditions.

Global processes of urban growth lead to severe environmental impacts such as temperature increase with an intensification of the urban heat island effect, and hydrological changes with far reaching consequences for plant growth and human health and well-being. Urban trees can help to mitigate the negative effects of climate change by providing ecosystem services such as carbon storage, shading, cooling by transpiration or reduction of rainwater runoff. The extent of each ecosystem service is closely linked with the tree species as well as with a tree's age, size, structure and vitality. To evaluate the ecosystem services of urban trees, the process-based growth model CityTree was developed which is able to estimate not only tree growth but also the species-specific ecosystem services including carbon storage, transpiration and runoff, shading, and cooling by transpiration. The model was parametrized for the species small-leaved lime (Tilia cordata), robinia (Robinia pseudoacacia), plane (Platanus×acerifolia) and horse chestnut (Aesculus hippocastanum). The model validation for tree growth (stem diameter increment, coefficient of correlation=0.76) as well as for the water balance (transpiration, coefficient of correlation=0.92) seems plausible and realistic. Tree growth and ecosystem services were simulated and analyzed for Central European cities both under current climate conditions and for the future climate scenarios. The simulations revealed that urban trees can significantly improve the urban climate and mitigate climate change effects. The quantity of the improvements depends on tree species and tree size as well as on the specific site conditions. Such simulation scenarios can be a proper basis for planning options to mitigate urban climate changes in individual cities.

High antibiotic prescription rates in hospitalized children with human metapneumovirus infection in comparison to RSV infection emphasize the value of point-of-care diagnostics.

BACKGROUND: Respiratory infections are the main causes for hospitalization in children and a common reason for the initiation of antibiotic treatment. Rapid antigen detection tests and point-of-care mPCR-based assays provide a fast detection of viral pathogens. Nonetheless, the prescription rate of antibiotics for respiratory infections is exceedingly high. In particular, human metapneumovirus (hMPV) infections frequently cause antibiotic treatment. METHODS: Children hospitalized in our clinic with an acute respiratory infection between January 2008 and January 2013 were included in the present study. Data of 3799 children were analyzed retrospectively for clinical symptoms, laboratory findings, and antibiotic and inhalation treatment. We performed an in-house m-RT-PCR-ELISA method for pathogen detection. RESULTS: Pathogen detection was possible in 2464 patients. In 6.3%, hMPV and, in 24.0%, RSV were detected. Patients positively tested for hMPV received inhalation therapy in 62.9%; patients positive for RSV in 73.8%. Patients positive for hMPV were treated with antibiotics in 62.3%. Patients with RSV infection received antibiotic treatment in 44.4%; all others in 43.5%. Notably, a positive result in RSV-RADT was associated with reduced number of antibiotic treatment. CONCLUSION: hMPV infections inherit a two times higher probability of antibiotic treatment. There was no significant difference in laboratory findings or body temperature between hMPV infection and infections caused by other pathogens. Clinical symptoms seem not to differ from those in RSV illness. Nonetheless, RSV infections triggered significantly lower antibiotic prescription rates. A considerate application of a POC-mPCR for patients with RSV-like symptoms and age of 1 year and older with a negative RSV-RADT might lead to higher detection rates of hMPV and a reduction in prescription of antibiotics.

Measurement of the in-medium K0 inclusive cross section in pi(-) -induced reactions at 1.15 GeV/c.

The K0 meson production by pi(-) mesons of 1.15 GeV/c momentum on C, Al, Cu, Sn, and Pb nuclear targets was measured with the FOPI spectrometer at the Schwer-Ionen-Synchrotron accelerator of GSI. Inclusive production cross sections and the momentum distributions of K0 mesons are compared to scaled elementary production cross sections and to predictions of theoretical models describing the in-medium production of kaons. The data represent a new reference for those models, which are widely used for interpretation of the strangeness production in heavy-ion collisions. The presented results demonstrate the sensitivity of the kaon production to the reaction amplitudes inside nuclei and point to the existence of a repulsive KN potential of 20+/-5 MeV at normal nuclear matter density.

Viral evolution toward change in receptor usage: adaptation of a major group human rhinovirus to grow in ICAM-1-negative cells.

Major receptor group common cold virus HRV89 was adapted to grow in HEp-2 cells, which are permissive for minor group human rhinoviruses (HRVs) but which only marginally support growth of major-group viruses. After 32 blind passages in these cells, each alternating with boosts of the recovered virus in HeLa cells, HRV89 acquired the capacity to effectively replicate in HEp-2 cells, attaining virus titers comparable to those in HeLa cells although no cytopathic effect was observed. Several clones were isolated and shown to replicate in HeLa cells whose ICAM-1 was blocked with monoclonal antibody R6.5 and in COS-7 cells, which are devoid of ICAM-1. Blocking experiments with recombinant very-low-density lipoprotein receptor fragments and enzyme-linked immunosorbent assays indicated that the mutants bound a receptor different from that used by minor-group viruses. Determination of the genomic RNA sequence encoding the capsid protein region revealed no changes in amino acid residues at positions equivalent to those involved in the interaction of HRV14 or HRV16 with ICAM-1. One mutation was within the footprint of a very-low-density lipoprotein receptor fragment bound to minor-group virus HRV2. Since ICAM-1 not only functions as a vehicle for cell entry but has also a "catalytic" function in uncoating, the use of other receptors must have important consequences for the entry pathway and demonstrates the plasticity of these viruses.

[Clinical and radiological results after arthroscopic partial medial meniscectomy. Are there risk factors?]. / Klinische und radiologische Ergebnisse nach arthroskopischer partieller Innenmeniskusresektion. Gibt es prädisponierende Faktoren?

In a retrospective study 100 patients underwent a clinical and radiological follow-up 7 years and 7 months after an arthroscopic partial medial meniscectomy. None of these patients had associated intraarticular lesions apart a minor chondral damage of the medial compartment. The follow-up showed excellent clinical results in 96% of patients according to the modified Marshall Score. The radiological results demonstrated a deterioration or development of osteoarthritis of the operated knee joint in 33% of patients, with a statistical significance between radiological and clinical results (p < 0.05). The age of the patients at time of operation and any angular deformity of the knee joint had no statistical significant influence on the radiological results. Women had a statistically significant higher risk to deteriorate or develop gonarthrosis after partial medial meniscectomy than men (p < 0.05). The arthroscopic partial medial meniscectomy leads to excellent subjective and functional results, but it could not totally prevent the increase or development of degenerative changes in the medial knee compartment.

Accumulation of organic air constituents by plant surfaces. Spruce needles for monitoring airborne chlorinated hydrocarbons.

The needles of the spruce (Picea abies) were used to monitor ambient air for organic trace substances. Analyses of spruce needles in an industrialized area demonstrated that the concentrations of these substances were much higher than those in a nonindustrialized area.