RESUMO
Experimental studies of the mussels hydrolysate (MIGI-K) have shown that this preparation can enhance the radioresistance and general resistance of the organism. The mechanisms of its action are related mainly with its influence on the components of the biochemical back-ground of the resistance and with its antioxidative activity. Some properties of this preparation, for example, absence of toxicity and harmful side effects, made it possible as an adaptogene and as a remedy, increasing radionuclides excretion.
Assuntos
Aditivos Alimentares/uso terapêutico , Centrais Elétricas , Hidrolisados de Proteína/uso terapêutico , Lesões por Radiação/reabilitação , Protetores contra Radiação/uso terapêutico , Liberação Nociva de Radioativos , Animais , Bivalves , Humanos , Peroxidação de Lipídeos/efeitos dos fármacos , Peroxidação de Lipídeos/efeitos da radiação , Megacariócitos/efeitos dos fármacos , Megacariócitos/efeitos da radiação , Camundongos , Lesões por Radiação/sangue , UcrâniaRESUMO
Acid mussel hydrolisate MIGI-K LP is a food product, and a medical and prophylactic preparation containing a full set of irreplaceable amino acids (with the exception of thriptophane), essential fatty acids, macro- and microelements. MIGI-K LP can be used as a foot additive which improves the taste and increases the food qualities of the product, and as a medical preparation against some diseases.
Assuntos
Bivalves/metabolismo , Aditivos Alimentares/isolamento & purificação , Sequestradores de Radicais Livres/isolamento & purificação , Hidrolisados de Proteína/isolamento & purificação , Protetores contra Radiação/isolamento & purificação , Frutos do Mar , Adolescente , Adulto , Idoso , Aminoácidos/análise , Animais , Criança , Pré-Escolar , Ácidos Graxos/análise , Gastroenteropatias/dietoterapia , Hepatite B/dietoterapia , Hepatite C/dietoterapia , Humanos , Lactente , Pessoa de Meia-Idade , Controle de Qualidade , Oligoelementos/análiseRESUMO
Antiviral properties were found with a preparation obtained from mussel meat by acid hydrolysis. In the experiments in vitro this mussel hydrolysate reduced the infectious activity of influenza viruses in neutralization tests by 3-6 log. Applications of the preparation to mice infected with a toxigenic influenza virus strain protected from death 66-84% of the animals, the survival rate in controls being from 9 to 16%. The protective effect of mussel hydrolysate was observed both after intranasal and oral administrations. The optimal protective effect was obtained when the preparation was used 5-24 hours before inoculation.
Assuntos
Antivirais/farmacologia , Bivalves , Carne , Hidrolisados de Proteína/farmacologia , Animais , Antivirais/isolamento & purificação , Antivirais/uso terapêutico , Células Cultivadas , Embrião de Galinha , Depressão Química , Avaliação Pré-Clínica de Medicamentos , Vírus da Influenza A/efeitos dos fármacos , Vírus da Influenza B/efeitos dos fármacos , Camundongos , Infecções por Orthomyxoviridae/tratamento farmacológico , Infecções por Orthomyxoviridae/mortalidade , Hidrolisados de Proteína/isolamento & purificação , Hidrolisados de Proteína/uso terapêuticoRESUMO
Irradiation of rats by 131I (10 Gy) incorporated in the thyroid and by 137Cs external source (6 Gy) was made. Part of animals received a ration with Laminaria that reduced a rise in frequency of leukemia, other malignant tumors and increased latent period of tumor formation.
Assuntos
Alimentos , Laminaria/fisiologia , Leucemia Experimental/prevenção & controle , Neoplasias Induzidas por Radiação/prevenção & controle , Animais , Feminino , RatosRESUMO
The physico-chemical properties of preparation MIGI-K from mussels are given. Some characteristics of melanoidin fractions of MIGI-K are presented, their similarity to standard melanoidin is revealed. The given data on biological activity of the preparation permit to consider MIGI-K as immunomodulator.
