Stress Classification Using Brain Signals Based on LSTM Network.

The early diagnosis of stress symptoms is essential for preventing various mental disorder such as depression. Electroencephalography (EEG) signals are frequently employed in stress detection research and are both inexpensive and noninvasive modality. This paper proposes a stress classification system by utilizing an EEG signal. EEG signals from thirty-five volunteers were analysed which were acquired using four EEG sensors using a commercially available 4-electrode Muse EEG headband. Four movie clips were chosen as stress elicitation material. Two clips were selected to induce stress as it contains emotionally inductive scenes. The other two clips were chosen that do not induce stress as it has many comedy scenes. The recorded signals were then used to build the stress classification model. We compared the Multilayer Perceptron (MLP) and Long Short-Term Memory (LSTM) for classifying stress and nonstress group. The maximum classification accuracy of 93.17% was achieved using two-layer LSTM architecture.

Novel Genetic Locus Influencing Retinal Venular Tortuosity Is Also Associated With Risk of Coronary Artery Disease.

OBJECTIVE: The retina may provide readily accessible imaging biomarkers of global cardiovascular health. Increasing evidence suggests variation in retinal vascular traits is highly heritable. This study aimed to identify the genetic determinants of retinal vascular traits. Approach and Results: We conducted a meta-analysis of genome-wide association studies for quantitative retinal vascular traits derived using semi-automatic image analysis of digital retinal photographs from the GoDARTS (Genetics of Diabetes Audit and Research in Tayside; N=1736) and ORCADES (Orkney Complex Disease Study; N=1358) cohorts. We identified a novel genome-wide significant locus at 19q13 (ACTN4/CAPN12) for retinal venular tortuosity (TortV), and one at 13q34 (COL4A2) for retinal arteriolar tortuosity (TortA); these 2 loci were subsequently confirmed in 3 independent cohorts (Ntotal=1413). In the combined analysis of discovery and replication cohorts, the lead single-nucleotide polymorphism in ACTN4/CAPN12 was rs1808382 (ßs.d.=-0.109; SE=0.015; P=2.39×10-13) and in COL4A2 was rs7991229 (ßs.d.=0.103; SE=0.015; P=4.66×10-12). Notably, the ACTN4/CAPN12 locus associated with TortV is also associated with coronary artery disease, heart rate, and atrial fibrillation. CONCLUSIONS: Genetic determinants of retinal vascular tortuosity are also linked to cardiovascular health. These findings provide a molecular pathophysiological foundation for the use of retinal vascular traits as biomarkers for cardiovascular diseases.