An open-source platform for interactive collision prevention in photon and particle beam therapy treatment planning.

We present an open-source platform to aid medical dosimetrists in preventing collisions between gantry head and patient or couch during photon or particle beam therapy treatment planning. This generic framework uses the native scripting interface of the particular planning software to import STL files of the treatment machine elements. These are visualized in 3D together with the contoured or scanned patient surface. A graphical dialog with sliders allows the interactive rotation of the gantry and couch, with real-time feedback. To prevent a future replanning, treatment planners can assess in advance and exclude beam angles resulting in a potential risk of collision. The software platform is publicly available on GitHub and has been validated for RayStation with actual patient plans. Furthermore, the incorporation of the complete patient geometry was tested with a 3D surface scan of a full-body phantom performed with a handheld smartphone. With this study, we aim at minimizing the risk of replanning due to collisions and thus of treatment delays and unscheduled consumption of manpower. The clinical workflow can be streamlined at no cost already at the treatment planning stage. By ensuring a real-time verification of the plan feasibility, the script might boost the use of optimal couch angles that a planner might shy away from otherwise.

Comparative analysis of macromolecules in mollusc shells.

1. Proteins and polysaccharides were isolated from the shells of molluscs; blue mussel, Mytilus edulis, chambered nautilus, Nautilus pompilius, and red abalone, Haliotus rufescens. 2. N-acetyl glucosamine was detected in nautilus but not mussel or abalone. 3. Amino acid analysis of protein fractions was completed for the three molluscs and purified proteins from the mussel were partially sequenced. 4. Calcium binding studies were carried out with some of the protein fractions.