Pd(II)-Catalyzed ß-C(sp3)-H Alkynylation of Alanine in Di- and Tripeptides with Asn as an Endogenous Directing Group.

The introduction of alkyne moieties into peptides remains in demand as it represents a promising approach for further structural diversification of peptides. Herein, we describe the Pd(II)-catalyzed C(sp3)-H alkynylation of Ala-Asn-embedded di- and tripeptides using Asn as the endogenous lead group. In addition, a key building block for the glycopeptide Tyc4PG-14 and Tyc4PG-15 was produced by our methodology.

Identification of novel 3-aryl-1-aminoisoquinolines-based KRASG12C inhibitors: Rational drug design and expedient construction by CH functionalization/annulation.

Developing a synthetic methodology to expediently construct a specific drug scaffold with the desired biological activity remains challenging. Herein, we describe a work on rational application of a synthetic methodology in the synthesis of KRASG12C inhibitors. Novel KRASG12C inhibitors were initially designed with 1-amino-3-aryl isoquinoline scaffold using structure-based drug design strategy. A ruthenium-catalyzed direct monoCH functionalization/annulation cascade reaction of amidines and sulfoxonium ylides was then developed with high versatility of substrates and good tolerance for polar functional groups. By using this reaction, the target compounds 1-amino-3-aryl isoquinolines were facilely prepared. Further in vitro tests led to identification of two novel lead compounds with KRASG12C inhibitory activity.

Observation of nonlinear disclination states.

Introduction of controllable deformations into periodic materials that lead to disclinations in their structure opens novel routes for construction of higher-order topological insulators hosting topological states at disclinations. Appearance of these topological states is consistent with the bulk-disclination correspondence principle, and is due to the filling anomaly that results in fractional charges to the boundary unit cells. So far, topological disclination states were observed only in the linear regime, while the interplay between nonlinearity and topology in the systems with disclinations has been never studied experimentally. We report here on the experimental observation of the nonlinear photonic disclination states in waveguide arrays with pentagonal or heptagonal disclination cores inscribed in transparent optical medium using the fs-laser writing technique. The transition between nontopological and topological phases in such structures is controlled by the Kekulé distortion coefficient r with topological phase hosting simultaneously disclination states at the inner disclination core and spatially separated from them corner-I, corner-II, and extended edge states at the outer edge of the structure. We show that the robust nonlinear disclination states bifurcate from their linear counterparts and that location of their propagation constants in the gap and, hence, their spatial localization can be controlled by their power. Nonlinear disclination states can be efficiently excited by Gaussian input beams, but only if they are focused into the waveguides belonging to the disclination core, where such topological states reside. Our results open new prospects for investigation of nonlinear effects in topological systems with disclinations and are relevant for different areas of science, including Bose-Einstein and polariton condensates, where potentials with the disclinations can be created.

Valley Hall edge solitons in a photonic graphene.

We predict the existence and study properties of the valley Hall edge solitons in a composite photonic graphene with a domain wall between two honeycomb lattices with broken inversion symmetry. Inversion symmetry in our system is broken due to detuning introduced into constituent sublattices of the honeycomb structure. We show that nonlinear valley Hall edge states with sufficiently high amplitude bifurcating from the linear valley Hall edge state supported by the domain wall, can split into sets of bright spots due to development of the modulational instability, and that such an instability is a precursor for the formation of topological bright valley Hall edge solitons localized due to nonlinear self-action and travelling along the domain wall over large distances. Topological protection of the valley Hall edge solitons is demonstrated by modeling their passage through sharp corners of the Ω-shaped domain wall.

Controllable switch of a transmittance signal via polarization combination manipulation.

We propose and experimentally demonstrate a process in which we can control the behavior of an atomic medium to switch on or off transmittance signals at multiple frequencies in ladder-type electromagnetically induced transparency (EIT) of 5S1/2-5P3/2-5D3/2 transition of Rb87 atoms. By adjusting the polarizations of the applied optical fields, the amplitudes of the transmittance spectra at multiple frequency channels can be controlled. This mechanism originates from the competition between EIT subsystems and single-photon absorption with a contribution from different transition strengths. Moreover, we also analyze the influences of the intensity and detuning of the coupling field on the transmitted signals when two lasers are perpendicular, linearly polarized lights, and observe electromagnetically induced absorption due to quantum constructive interference. Detailed theoretical analyses, including the different strengths in different transitions and Doppler broadening, agree with the experimental observations.