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1.
Org Lett ; 25(1): 93-98, 2023 01 13.
Artigo em Inglês | MEDLINE | ID: mdl-36546834

RESUMO

The construction of molecular skeletons and modification of molecules using widely available and easily prepared alcohols as radical precursors for coupling reactions are significant and challenging subjects. We herein report a straightforward strategy for the dehydrogenative ring-opening alkenylation of cycloalkanols with alkenes by combining a proton-coupled electron transfer strategy and a dual photoredox and cobalt catalysis system. With this approach, a series of distally unsaturated ketones were obtained in 17-83% yields with high E selectivity.


Assuntos
Álcoois , Prótons , Humanos , Transporte de Elétrons , Catálise , Alcenos , Cobalto
2.
Chem Sci ; 13(26): 7947-7954, 2022 Jul 06.
Artigo em Inglês | MEDLINE | ID: mdl-35865906

RESUMO

The transformations that allow the direct removal of hydrogen from their corresponding saturated counterparts by the dehydrogenative strategy are a dream reaction that has remained largely underexplored. In this report, a straightforward and robust cobaloxime-catalyzed photochemical dehydrogenation strategy via intramolecular HAT is described for the first time. The reaction proceeds through an intramolecular radical translocation followed by the cobalt assisted dehydrogenation without needing any other external photosensitizers, noble-metals or oxidants. With this approach, a series of valuable unsaturated compounds such as α,ß-unsaturated amides, enamides and allylic and homoallylic sulfonamides were obtained in moderate to excellent yields with good chemo- and regioselectivities, and the synthetic versatility was demonstrated by a range of transformations. And mechanistic studies of the method are discussed.

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