First Clinical Application of Polyurethane Meniscal Scaffolds with Mesenchymal Stem Cells and Assessment of Cartilage Quality with T2 Mapping at 12 Months.

BACKGROUND: Complex meniscal lesions often require meniscectomy with favorable results in the short term but a high risk of early osteoarthritis subsequently. Partial meniscectomy treated with meniscal substitutes may delay articular cartilage degeneration. PURPOSE: To evaluate the status of articular cartilage by T2 mapping after meniscal substitution with polyurethane scaffolds enriched with mesenchymal stem cells (MSC) and comparison with acellular scaffolds at 12 months. METHODS: Seventeen patients (18-50 years) with past meniscectomies were enrolled in 2 groups: (1) acellular polyurethane scaffold (APS) or (2) polyurethane scaffold enriched with MSC (MPS). Patients in the MPS group received filgrastim to stimulate MSC production, and CD90+ cells were obtained and cultured in the polyurethane scaffold. The scaffolds were implanted arthroscopically into partial meniscus defects. Concomitant injuries (articular cartilage lesions or cartilage lesions) were treated during the same procedure. Changes in the quality of articular cartilage were evaluated with T2 mapping in femur and tibia at 12 months. RESULTS: In tibial T2 mapping, values for the MPS group increased slightly at 9 months but returned to initial values at 12 months (P > 0.05). In the APS group, a clear decrease from 3 months to 12 months was observed (P > 0.05). This difference tended to be significantly lower in the APS group compared with the MPS group at the final time point (P = 0.18). In the femur, a slight increase in the MPS group (47.8 ± 3.4) compared with the APS group (45.3 ± 4.9) was observed (P > 0.05). CONCLUSION: Meniscal substitution with polyurethane scaffold maintains normal T2 mapping values in adjacent cartilage at 12 months. The addition of MSC did not show any advantage in the protection of articular cartilage over acellular scaffolds (P > 0.05).

[Survival of the T28 femoral stem. Comparison of polished versus roughed-surface finish]. / Comparación de la supervivencia del vástago femoral (T28) con terminado liso o rugoso.

INTRODUCTION: Femoral stem loosening in total hip arthroplasty has a multifactorial etiology. T28 femoral stems have been made both roughed and polished-finish types, and differences in design are of interest in their effect on survival. MATERIALS AND METHODS: One hundred and sixty-seven stems (84 polished and 83 roughed-finish) placed between 1975 and 1982 were evaluated. Gruen zones were used to determine loosening and survival was determined by the Kaplan-Meier method. RESULTS: Revision was made in 24.8% of the cases. Twenty-year survival rates were of 85.2% for roughed-finish stems and of 64.2% for polished-finish stems. CONCLUSIONS: We were able to confirm our hypothesis concerning the longer survival rate of the roughed-finish implant which was of 87.95% at 17 years of follow-up. The survival-time of the implant was independent of diagnosis, cementation, age and positioning. The survival-time of the T28 cemented implant does not only depend on its texture but it has a multifactorial origin.

Eficacia comparativa entre los abordajes lateral y medial para corregir la deformidad en valgo mayor de 15 grados en la artroplastía total de la rodilla / Comparative trial betwenn medial and lateral approach for corrrecting valgus of the knee, greater than 15 degrees in total knee replacement

Objetivo. Valorar la conveniencia de utilizar el abordaje pararrotuliano lateral en la artoplastía total de la rodilla (ATR) en pacientes con valgo exagerado de la rodilla. Material y métodos. Se trata de un estudio retrospectivo de 13 mujeres (de un total de 14), operadas de ATR de 1995 a 2000, con un valgo preoperatorio mayor de 15 grados. Sin selección al azar, el abordaje lateral se usó en 6 (prom. 60.8 años y valgo 17.5º) y el medial en 7 (70.4 años, valgo 17.2º). La causa fue artrosis en los seis de abordaje medial y en cinco de los siete con abordaje lateral, y AR en los dos restantes. Resultados. Con base en los parámetros de dolor postoperatorio, estabilidad articular y arco de movimiento, los resultados fueron buenos en cuatro y malos en tres para el abordaje medial, mientras que fueron buenos en cinco y malos en uno para el abordaje lateral. El único resultado más notorio es la diferencia entre los resultados para el abordaje lateral, que parece orientarse a su favor, ya que en el caso del abordaje medial no hay diferencia alguna. Conclusión. El abordaje pararrotuliano lateral debe considerarse como una alternativa para la ATR en virtud de la tendencia aparente a cursar con menor proporción de complicaciones en pacientes con genu valgo exagerado.