1.
Eur J Immunol
; 48(6): 1074-1077, 2018 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29436709
RESUMO
Estrogen inducible Hoxb8 leads to conditional immortalization of hematopoietic precursors. These cells can be cultured and infected with the CRISPR/Cas9 system for genome editing, circumventing resource consuming generation of mouse models. The resultant cells retain their ability to differentiate into migratory dendritic cells.