RESUMO
Objective: The objective of the study is to investigate the association of interleukin-6 (IL6) promoter single-nucleotide polymorphisms rs1800797 (-597 G/A) and rs1800796 (-572 G/C) with obesity or metabolic syndrome in Mexican-Americans. Methods: The rs1800797 and rs1800796 single-nucleotide polymorphisms were genotyped in Mexican-Americans (n = 437) from South Texas, and results were correlated with measures of obesity and metabolic syndrome including body mass index, waist circumference, blood pressure, cholesterol, triglycerides, glucose, liver enzymes, plasma IL6 and high-sensitive C-reactive protein (hs-CRP). Results: Significant associations were found for the rs1800796 variant with increased waist circumference, insulin resistance, lower IL6 levels and higher hs-CRP levels. The rs1800797 variant showed no associations with metabolic traits but was associated with higher IL6 levels and lower hs-CRP levels. Conclusions: Findings in this study support the anti-inflammatory, anti-obesity and glucose homeostatic roles of IL6 in Mexican-American youth.
RESUMO
Tuberculosis (TB) remains a major global disease, and diabetes, which is documented to increase susceptibility to TB threefold, is also becoming pandemic. This susceptibility has been attracting extensive research interest. The increased risk of TB in diabetes may serve as a unique model to understand host susceptibility to specific pathogens in humans. To examine this rationale, we investigated the expression of reported TB candidate genes in a longitudinal diabetes study. Two genes, HK2 and CD28, emerged as potential culprits in diabetes-increased TB susceptibility.
Assuntos
Antígenos CD28/genética , Diabetes Mellitus Tipo 2/complicações , Hexoquinase/genética , Tuberculose/genética , Adulto , Idoso , Diabetes Mellitus Tipo 2/genética , Feminino , Seguimentos , Expressão Gênica , Predisposição Genética para Doença , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Tuberculose/epidemiologiaRESUMO
Transcultural nursing should be the main focus of the nurse in any setting. Increased mobility of society demonstrates the need to understand anthropologic and cultural differences. The Valley provides a laboratory in which transcultural nursing can be examined more closely. Cadena recommends that MA nurses remain open to personal feelings generated by relationships with MA patients. The astute nurse assesses each patient's level of assimilation and provides care based on the findings. Comprehensive communication and patient and family participation are the keys to successful transcultural nursing. Sensitivity to modesty and pride translates into professional understanding of holistic needs rather than humiliation and alienation of the patient. At VBMC, these concepts are translated into working systems through the UACs and the bedside-managed care delivery system.
Assuntos
Cultura , Serviços de Saúde do Indígena/organização & administração , Americanos Mexicanos , Serviço Hospitalar de Enfermagem/organização & administração , Enfermagem Transcultural , Comunicação , Atenção à Saúde/organização & administração , Humanos , Masculino , Pessoa de Meia-Idade , Inovação Organizacional , Texas , Enfermagem Transcultural/organização & administração , Visitas a PacientesRESUMO
The authors present an institution-wide approach to restructuring nursing practice. Unit action committees, restorative care paths, permanent care teams, and a physician/nurse liaison committee were four major strategies implemented. Nursing's major goals from this project were to increase autonomy, enhance collaborative practice, and reward with salary commensurate with management responsibility.
