[An open comparative observational study of the efficacy and safety of adaptol in anxiety-asthenic disorders in patients with chronic cerebral ischemia]. / Otkrytoe sravnitel'noe nablyudatel'noe issledovanie effektivnosti i bezopasnosti preparata adaptol v terapii trevozhno-astenicheskikh rasstroistv u bol'nykh s khronicheskoi ishemiei golovnogo mozga.

AIM: To assess the efficacy and safety of adaptol in anxiety-asthenic disorders in patients with chronic cerebral ischemia (CCI). MATERIAL AND METHODS: Forty-nine patients with CCI and comorbid anxiety-asthenic disorder were randomized to standard treatment group (20 patients) and main group which consisted of 29 patients treated with adaptol (500 mg 2 times daily for 6 weeks) in addition to standard treatment. The efficacy of treatment was assessed with HADS-A, HADS-D, FAS and SF-36. Physical fatigue was evaluated using cycle ergometry test. RESULTS: After 6 weeks, anxiety symptoms were stopped in the most of the patients of the main group (72.4%). The threshold during cycle ergometry was higher in the patients of the main group compared to the comparison group (132.2 vs 114.0 VT, respectively) and the patients experienced less fatigue after the test. Quality-of-life was improved by >10% in patients treated with adaptol and did not changed in the patients of the comparison group. CONCLUSION: The addition of adaptol to standard treatment of patients with CCI allows to stop symptoms of anxiety, increase the tolerance to load and improve quality-of-life.

[Characteristics of gender differences in patients with panic disorder].

The individual gender type was assessed using the Bem sex role inventory. Seventy patients with panic disorders (PD) and 50 healthy people (controls) were studied. There was a few patients with masculine features (4.3%) compared to the control group (22%). The correlations between a small number of masculine characteristics (less than 10 traits), the development of agoraphobia in PD, the progressive course of PD with the poor response to treatment and marked social maladaptation were found. It has been concluded that the insufficient masculinization is a personality feature of PD patients predisposing to avoidant behavior.

[Correlation of lipid spectrum with red blood cells izoantigene polymorphism and nutritional status of isetski believers].

In genetically homogeneous groups food habits associate with a number of food substances which act with food stuffs, and render essential influence on a lipid spectrum wheys of blood. Thus can influence character of current not only not infectious, but also on infectious inflammatory diseases which associate with secondary immune.