1.
Microbes Infect
; 4(11): 1193-202, 2002 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12361920
RESUMO
Leprosy is a chronic infection of the skin and nerves caused by Mycobacterium leprae. Erythema nodosum leprosum (ENL) is a reactive state in lepromatous leprosy. Thalidomide has been used to treat ENL since the 1960s. One of its mechanisms of action is anti-inflammatory through selective inhibition of the pro-inflammatory cytokine TNF-alpha produced by monocytes.
Assuntos
Hansenostáticos/uso terapêutico , Hanseníase/tratamento farmacológico , Talidomida/uso terapêutico , Quimioterapia Combinada , Eritema Nodoso/tratamento farmacológico , Eritema Nodoso/patologia , Humanos , Incidência , Hanseníase/patologia , Hanseníase/transmissão , Hanseníase Virchowiana/tratamento farmacológico , Hanseníase Virchowiana/patologia , Modelos Moleculares , Mycobacterium leprae/patogenicidade , Talidomida/efeitos adversos , Talidomida/farmacocinética , Talidomida/farmacologia , Fator de Necrose Tumoral alfa/metabolismo
2.
s.l; s.n; 2002. 10 p. ilus, tab.
Não convencional
em Inglês
| Sec. Est. Saúde SP, HANSEN, Hanseníase, SESSP-ILSLACERVO, Sec. Est. Saúde SP
| ID: biblio-1240941
RESUMO
Leprosy is a chronic infection of the skin and nerves caused by Mycobacterium leprae. Erythema nodosum leprosum (ENL) is a reactive state in lepromatous leprosy. Thalidomide has been used to treat ENL since the 1960s. One of its mechanisms of action is anti-inflammatory through selective inhibition of the pro-inflammatory cytokine TNF-alpha produced by monocytes.
