Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Bioorg Med Chem Lett ; 109: 129826, 2024 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-38830427

RESUMO

Carvacrol, called CA, is a dynamic phytoconstituent characterized by a phenol ring abundantly sourced from various natural reservoirs. This versatile scaffold serves as a pivotal template for the design and synthesis of novel drug molecules, harboring promising biological activities. The active sites positioned at C-4, C-6, and the hydroxyl group (-OH) of CA offer fertile ground for creating potent drug candidates from a pharmacological standpoint. In this comprehensive review, we delve into diverse synthesis pathways and explore the biological activity of CA derivatives. We aim to illuminate the potential of these derivatives in discovering and developing efficacious treatments against a myriad of life-threatening diseases. By scrutinizing the structural modifications and pharmacophore placements that enhance the activity of CA derivatives, we aspire to inspire the innovation of novel therapeutics with heightened potency and effectiveness.


Assuntos
Cimenos , Descoberta de Drogas , Cimenos/química , Cimenos/farmacologia , Cimenos/síntese química , Humanos , Estrutura Molecular , Animais , Relação Estrutura-Atividade , Monoterpenos/química , Monoterpenos/farmacologia , Monoterpenos/síntese química
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...