Assuntos
Cruzamento , Doenças dos Bovinos/genética , Doença da Urina de Xarope de Bordo/veterinária , 3-Metil-2-Oxobutanoato Desidrogenase (Lipoamida) , Animais , Animais Recém-Nascidos , Encéfalo/patologia , Bovinos , Doenças dos Bovinos/patologia , Cetona Oxirredutases/deficiência , Doença da Urina de Xarope de Bordo/genética , Doença da Urina de Xarope de Bordo/patologia , Complexos Multienzimáticos/deficiência , Austrália OcidentalRESUMO
Chronic hepatitis and increased hepatic copper concentrations, from 1,600 to 6,361 micrograms/g dry tissue were found in 4 related, Australian-bred Bedlington terriers. Two dogs were asymptomatic and 2 were clinically ill with signs referable to liver dysfunction. Two dogs were treated with d-penicillamine. After one year there was no improvement in the histopathological liver changes in either dog or significant lowering of hepatic copper level in one dog.
Assuntos
Cobre/intoxicação , Doenças do Cão/genética , Hepatite/genética , Erros Inatos do Metabolismo/veterinária , Animais , Doença Crônica , Cobre/metabolismo , Doenças do Cão/metabolismo , Cães , Feminino , Hepatite/metabolismo , Fígado/metabolismo , Masculino , Erros Inatos do Metabolismo/genética , Erros Inatos do Metabolismo/metabolismoRESUMO
Ventricular septal defects were diagnosed in 3 familially-related Saanen goats, a 4-year-old doe and 2 female kids aged 18 weeks, by clinical examination, electrocardiography, phonocardiography and thoracic radiography. Findings were contrasted with those from 3 clinically normal goats. Cardiac catheterisation was attempted on the 2 affected kids before euthanasia. Blood pressure tracings and selective contrast cardioangiography successfully demonstrated the defect in one case, but the other died shortly after anaesthetic induction. The adult goat, suspected paternal grand-dam of the affected twins, died without premonitory signs at 4.5 years of age. Necropsy confirmed the diagnosis in all 3 cases.
