RESUMO
The evaluation of intima-media thickening (IMT) of carotid artery is an important parameter in preclinical diagnosis of atherosclerosis and stroke risk in hypertensive patients. Measurements of carotid wall thickness via Doppler were considered to be valuable in prediction of risk of brain damage and future stroke due to hypertension in diabetic and non-diabetic patients.
Assuntos
Estenose das Carótidas/diagnóstico , Diabetes Mellitus/epidemiologia , Hipertensão/epidemiologia , Acidente Vascular Cerebral/diagnóstico , Acidente Vascular Cerebral/epidemiologia , Idoso , Humanos , Fatores de RiscoRESUMO
Diabetes mellitus is one of the main risk factors of cerebrovascular disease (CVD). Comparing non-diabetic and diabetic patients, the latter ones have a higher incidence of stroke, which tends to occur at younger ages. This paper deals with Echo Doppler evaluation of arteries in diabetic and non-diabetic patients. The findings allow us to conclude that the correct and early treatment of diabetes as well as a possible lowering of the risks for cerebrovascular disease are obligatory steps in the primary and secondary prevention of the cerebral ischemic events in diabetic patients with carotid atheromatous lesions. This consideration may help the physicians to have a deeper understanding of the pathophysiology, and to implement the necessary treatment and prevention of CVD in the diabetic population of high-risk.
Assuntos
Estenose das Carótidas/diagnóstico , Estenose das Carótidas/epidemiologia , Diabetes Mellitus Tipo 2/epidemiologia , Ecocardiografia Doppler/métodos , Arteriosclerose Intracraniana/diagnóstico , Arteriosclerose Intracraniana/epidemiologia , Doenças Vasculares Periféricas/epidemiologia , Idoso , Doenças das Artérias Carótidas/diagnóstico , Doenças das Artérias Carótidas/epidemiologia , Humanos , Ataque Isquêmico Transitório/epidemiologiaRESUMO
Endogenous and exogenous Na-glutamate (Glu) accumulation in central nervous system (CNS) may be involved in neuronal death, leading to neurodegenerative disorders in humans. This paper describes the effect of in vivo and in vitro Glu treatment on rat bioelectric activity in hypothalamus (HT) and cerebral cortex (C), as well as the measurement of brain enzyme activities involved in the metabolism and transport of Glu in brain cells.Glu may be a key factor in the onset of neuronal cell death by changing the cell energetics, the cellular redox-potential, due to a decreased free radical scavenging capacity.
Assuntos
Hipotálamo/efeitos dos fármacos , Glutamato de Sódio/farmacologia , Glutamato de Sódio/uso terapêutico , gama-Glutamiltransferase/efeitos dos fármacos , Animais , Morte Celular/efeitos dos fármacos , Córtex Cerebral/efeitos dos fármacos , Neurônios/efeitos dos fármacos , Neurônios/patologia , Oxirredução/efeitos dos fármacos , RatosRESUMO
With rapidly growing geriatric population and with the improvement in quality of life, sexuality is becoming an increasingly important aspect of aging. This paper is dealing with the investigation of the role of physical training program of moderate intensity on endocrine modulation, skeletal muscle physiology, improvement of depression and of sexual function in elderly men.
