1.
European J Org Chem
; 26(35)2023 Sep 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37927304
RESUMO
Lycorane is a pentacyclic core presented in alkaloids isolated from the Amaryllidaceae family of herbaceous flowering plants. Members of this class of natural products have shown to display important biological properties including analgesic, antiviral, and antiproliferative activities. This review presents the known synthetic routes toward α-, ß-, γ-, and δ-lycoranes. α-(19 routes), ß-(10 routes), γ-(38 routes), and δ-(6 routes).
2.
Bioorg Med Chem Lett
; 28(15): 2627-2630, 2018 08 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29937060
RESUMO
We have developed versatile methods toward the synthesis of a variety of piperidine/piperazine bridged isosteres of pridopidine. The compounds were assessed against the D2 receptor in agonist and antagonist modes and against the D4 receptor in agonist mode. hERG Binding and the ADME profiles were studied.