A comparison of the efficacy of autologous fibrin glue/platelet-poor plasma versus suction drainage in preventing hematoma and seroma in rhytidectomy: A randomized, double-blind, controlled study.

BACKGROUND: One of the most feared complications of rhytidectomy is the formation of hematoma and seroma, which may harm patients' health and compromise the surgical outcome. OBJECTIVE: To compare the efficacy of autologous fibrin glue/platelet-poor plasma versus suction drainage in preventing surgical complications such as hematoma and seroma following rhytidectomy procedures. METHODS: A prospective, randomized, double-blind, controlled study was conducted to compare the efficacy of the two interventions. Seventy-two patients were selected and divided into two groups of 36 (autologous fibrin glue versus suction drainage). Forty-eight hours after the procedures, all patients underwent ultrasound examination, always by the same radiologist, to measure the volume of exudate under the facial skin flaps. RESULTS: The mean total volume of exudate was 3.21 mL in the suction drainage group and 1.02 mL in the fibrin glue group, with effect size of 68.1% and confidence interval of 55.3 to 77.2 (P < 0.001). CONCLUSIONS: Results significantly favor the use of fibrin glue and show that it was 68.1% more effective than suction drainage in preventing hematoma or seroma in rhytidectomy procedures.

Sources of processed lipoaspirate cells: influence of donor site on cell concentration.

BACKGROUND: Recently, adipose tissue harvested by liposuction has been identified as a source of processed lipoaspirate cells. The aim of this study was to determine the concentration of processed lipoaspirate cells in adipose tissue obtained by liposuction from different harvest areas in women. METHODS: A prospective cross-sectional study was conducted in 25 women in whom liposuction in four or more different zones in the same procedure was indicated. After selective liposuction, the material was sent to the laboratory, where it was processed for extraction of processed lipoaspirate cells, which were separated from the adipose tissue, quantified, and characterized through determination of c-kit expression. The following harvest regions were evaluated: upper abdomen, lower abdomen, trochanteric region, inner thigh, knee, and flank. The cell concentration obtained at each site was compared by analysis of variance for mixed models. RESULTS: A significant difference was found for cell concentration obtained at the different harvest sites. The cell concentration in the lower abdomen was greater than in other areas, but no significant difference was found in relation to the inner thigh. CONCLUSIONS: The lower abdomen and the inner thigh may have higher processed lipoaspirate cell concentrations. These sites may turn out to be better sources of adult mesenchymal stem cells.

Utilização de anestésico local em mamaplastia: um estudo duplo-cego placebo controlado com alocação aleatória / Local anesthetic use in mammoplasty: a randomized double-blind placebo controlled study

Introdução: analgesia pré-incisional é um tratamento para a dor que previne alterações centrais de excitabilidade derivada de intensos estímulos nociceptivos.objetivos: Foi desenhado um ensaio clínico randomizado, duplo-cego placebo controlado buscando determinar a eficácia analgésica da infiltração pré- operatória de bupivacaína em mamaplastia redutora. Métodos: Mulheres com hipertrofia mamária foram alocadas ao acaso em um dos dois grupos. Pacientes no grupo 1 receberam, em cada mama, infiltração com bupivacaína após anestesia geral e antes da incisão. Pacientes do grupo 2 receberam injeções similares contendo apenas solução salina. Resultados: Escala Verbal da Dor, Escala Analógica Visual da Dor e Questionário de McGill Resumido aplicados 22 horas após a cirurgia obtiveram valores maiores nos pacientes do grupo 2 (p<0,008). Pacientes no grupo da solução salina tiveram um maior consumo de meperidina durante estas 22 horas de pós-operatório e solicitaram opióides antes do que os pacientes do grupo de bupivacaína (p<0,001), as diferenças entre os grupos foram estatisticamente significativas. Discussão: A infiltração pré-incisional com bupivacaína resultou em diminuição da dor e do consumo de opióides na fase inicial da dor pós-operatória. Conclusão: Neste estudo a infiltração pré-incisional de bupivacaína reduziu a dor após mamaplastia.

Background: Preincisional analgesia is an antinociceptive treatment that prevents altered central excitability from high intensity noxious stimuli. Objectives: In aim to determine the analgesic efficacy of preoperative infiltration with bupivacaine for reduction mammoplasty a randomized, double-blind, placebocontrolled trial were designed. Methods: Women with mammary hypertrophy were randomly allocated to one of two study groups. Patients in group 1 received preincision infiltration with bupivacaine into each breast after general anesthesia. Group 2 patients received similar injections of saline injection alone. Results: Visual analog pain score, verbal pain score and short-form McGill questionnaire scores were higher in group 2 patients until 22 hours after surgery (p<0,008). Patients in the saline group had higher intravenous meperidine consumption during the 22-hours postoperative and solicited opióides before than the patients in the bupivacaína group (p<0,001),thedifferencebetweengroupswerestatistically significant. Discussion: Preincisional infiltration with bupivacaine results in reduced pain and lower postoperative opioid requirements in the early postoperative phase of pain. Conclusion: In this study preincisional infiltration with bupivacaine have reduced the pain after mammoplasty.