[The immunotropic activity of GABA during cytochrome P-450 induction in the liver]. / Immunotropnaia aktivnost' GAMK v usloviiakh induktsii tsitokhroma P-450 v pecheni.

Gamma-aminobutyric acid (GABA) was shown to exert the immunodepressive effect. The use of GABA under induction of cytochrome P-450 of the liver by phenobarbital or rifampicin was not followed by immunodepression. The obtained data indicate the dependence of GABA pharmacological activity from the function of cytochrome P-450-dependent monooxygenase system of the liver.

[Morphological substantiation of treatment of liver cirrhosis with retabolil]. / Morfologicheskoe obosnovanie lecheniia retabolilom tsirroza pecheni.

The effect of retabolil on experimental liver cirrhosis in rats was studied. The results of the treatment point to a beneficial action of retabolil on the course of this malady, which found its expression in the prevalence regeneration manifestations over the processes of degeneration, as well as in the inhibitory effect on the development of liver cirrhosis. From morphometric investigations it follows that for retabolil the structure-target is the nucleonic system of the cells, largely of hepatocytes.