[Prevention of disorders of cardiac contractility with nicotinamide in adriblastin -related damage]. / Preduprezhdenie narushenii sokratitel'noi funktsii serdtsa pri adriblastinovom povrezhdenii s pomoshch'iu nikotinamida.

Pretreatment with 20 mg/kg nicotinamide 3 days prior to a single intraperitoneal 6 mg/kg adriblastin injection, followed by repeated injections every second days for 1 week, prevented cardiac contractility disorders in adriblastin-treated rats, while their cardiac contractility was less prone to hypoxic depression and recovered better at subsequent reoxygenation.

[Resistance of the myocardium to hypoxia and reoxygenation in rats of different genetic lines]. / Rezistentnost' serdechnoi myshtsy k gipoksii i reoksigenatsii u krys raznykh geneticheskikh linii.

The contractility of the myocardium in isovolume regimen of the heart activity was characterized by a considerably lower level of relaxation in the August line rats than in nonspecific rats. The coronary flow was found to be significantly reduced in the August and VAG line rats. The sensitivity to hypoxia was higher in the August line rats than in nonspecific ones. The VAG line rats were less resistant against the following reoxygenation.

[Prevention of disorders of the contractile function of the heart after chemical induction of lipid peroxides]. / Preduprezhdenie narushenii sokratitel'noi funktsii serdtsa pri khimicheskoi induktsii perekisnogo okisleniia lipidov.

Adriblastin was shown to activate considerably lipid peroxidation processes in the heart muscle, mostly through the suppression of antioxidant enzyme (superoxidedysmutase and catalase) activity, with myocardial contractility declining essentially as a result. Pretreatment with the synthetic antioxidant ionol prevented the adriblastin-induced depression of myocardial contractility.