[Structure-activity status of the rat liver lysosomal apparatus upon the action of dithiocarbamate pesticides]. / Strukturno-funktsional'noe sostoianie lizosomnogo apparata pecheni krys pri deistvii pestitsidov ditiokarbamatnogo riada.

Total and non-sedimentable activity of cathepsins A, B, C and D in rat liver tissue as well as activity of these lysosomal proteinases in blood serum were studied during intragastric administration of tetramethyl thiuramdisulfide (TMTD), polymartsine and tsineb within 30 days at a dose of 1/20 LD50. The enzymatic activity alterations, which involved a decrease in total activity of lysosomal proteinases and an increase of the activity in non-sedimentable fraction and blood serum, were distinctly decreased in series: TMTD--polymartsine--tsineb. The data obtained suggest that structure-functional state of lysosomes was considerably altered in response to the effect of dithiocarbamate-containing pesticides.