Magnetic Rubber@Ni-Co layered double hydroxide derived from ZIF-67 template as nanostructured sorbent; application in determination of anticancer drugs in plasma samples.

In this study, a magnetic three-dimensional nano-composite based on Rubber-Fe3O4@Ni-Co Layered double hydroxide derived from ZIF-67 template was synthesized by a hydrothermal method. The proposed nano-composite was used as a sorbent for the enrichment of trace amounts of anti-cancer drugs (dasatinib and erlotinib hydrochloride) from plasma samples followed by determination using high-performance liquid chromatographic analysis (HPLC-UV). The synthesized nano-sorbent was characterized by X-ray diffraction, field emission scanning electron microscopy, Fourier transform infrared spectroscopy, vibrating-sample magnetometer, Brunauer-Emmett-Teller surface analysis, Barrett-Joyner-Halenda pore size analysis and energy dispersive X-ray spectroscopy. Under optimal experimental conditions, factors affecting on extraction efficiency such as pH, ionic strength, extraction temperature and time, desorption solvent and time, the limit of detection (LODs) and the limit of quantification (LOQs) were obtained as 0.6, 2 µg/L for both of dasatinib and erlotinib, respectively. Also, linear range of the method were 2-500 and 2-1000 µg/L for dasatinib and erlotinib, respectively. Relative standard deviations (RSD%) for the repeatability of extraction on sorbent to sorbent were obtained as 3.59, 1.97 %, and one sorbent reusability were investigated and relative standard deviation values were obtained 5.35, 3.30 % for dasatinib and erlotinib, respectively.

Magnetic Rubber@ magnesium aluminum layered double hydroxide as nanostructured sorbent; application in determination of estrogenic hormones and bisphenol A.

A magnetic solid-phase extraction (MSPE) method was developed for the enrichment of trace amounts of estrone (E1), 17-ß-estradiol (E2) and bisphenol A (BPA) from aqueous samples using the Rubber-Fe3O4@SiO2@Mg-Al Layered double hydroxide followed by determination by HPLC. The proposed sorbent was characterized by X-ray diffraction, Field emission scanning electron microscopy, Fourier transform infrared spectroscopy, Vibrating-sample magnetometer, Thermal gravimetric analysis, N2 adsorption/desorption Brunauer-Emmett-Teller surface analysis, Barrett-Joyner-Halenda pore size analysis and Energy dispersive X-ray spectroscopy. Factors affecting the extraction efficiency such as pH, ionic strength, extraction temperature and time, desorption solvent and time were optimized. The limit of detection and quantification were obtained as 0.33, 1 µg L-1 for the E1 and E2 and BPA, respectively. Also, linear range of the method were 1-150, 1-100 and 1-150 µg L-1for E1, E2, and BPA, respectively. Relative standard deviations (RSD%) for the repeatability of extraction on one sorbent were obtained as 2.98, 1.31 and 3.50%, also, sorbent to sorbent repeatability were investigated and RSD% values were obtained as 7.58, 8.35 and 8.12% for E1, E2 and BPA, respectively.