Do the cardiovascular risk profile and the degree of arterial wall calcification influence the performance of MDCT angiography of lower extremity arteries?

OBJECTIVES: To retrospectively assess the influence of arterial wall calcifications on the accuracy of run-off computed tomographic angiography (CTA) and to analyse whether cardiovascular risk factors are predictors of compromising calcifications. METHODS: In 200 consecutive patients who underwent run-off CTA, calcifications were assessed in pelvic, thigh and calf arteries using a four-point scale. Fifty-nine patients with digital subtraction angiography (DSA) were assessed by both techniques to estimate a threshold of compromising calcifications, defined as a decrease of sensitivity, specificity, PPV or NPV below the lower 95% confidence interval of overall results. Regression analysis was performed to investigate a potential relationship between compromising calcifications and presence of cardiovascular risk factors, advanced patient age and severe peripheral arterial disease (PAD). RESULTS: The highest Ca(++)-score was chosen as the cut-off for the regression analysis, as a relevant decrease of specificity (0.91; overall: 0.95) above the knee and of sensitivity (0.66; overall: 0.83), specificity (0.65; overall: 0.93), positive predictive value (PPV) and negative predictive value (NPV) below the knee was observed. In the pelvic and thigh arteries, severe PAD (Fontaine Stage >or=III) showed the highest odds ratio for compromising calcifications (2.9), followed by diabetes mellitus (2.4), renal failure (2.1) and smoking (1.7). In the calf, renal failure (12.2) and diabetes mellitus (3.3) were the strongest predictors. CONCLUSIONS: Patients with diabetes and renal failure should be considered as candidates for alternative vessel imaging in order to avoid inconclusive examination results.

Quantitative and qualitative evaluation of the influence of different table feeds on visualization of peripheral arteries in CT angiography of aortoiliac and lower extremity arteries.

The influence of different table feeds (TF) on vascular enhancement and image quality in patients undergoing lower extremity runoff-CTA for peripheral artery occlusive disease (PAOD), acute ischemia (AI) or abdominal aortic aneurysm (AAA) with PAOD was investigated retrospectively. One hundred eighty-five patients (PAOD: n = 132; AI: n = 40; AAA: n = 13) underwent 16-detector runoff-CTA (120 kV; 140 mAs; rotation time 0.5 s, collimation 16 x 1.5 mm) using different TF (30 mm/s: n = 25; 40 mm/s: n = 91; 48 mm/s: n = 36; 56 mm/s: n = 33). Vascular enhancement of the large arteries was measured every 10 cm along the z-axis from the upper abdomen to the toe. Arterial enhancement in the distal lower leg was compared (ANOVA, Bonferroni post-test). Qualitative assessment of bolus timing was performed independently by two radiologists. The study was IRB approved. In patients with PAOD or AI, enhancement of calf arteries using a TF of 48 mm/s (278 +/- 79 HU) was significantly higher in comparison to two slower TF (30 mm/s: 201 +/- 70 HU, P < 0.001; 40 mm/s: 251 +/- 79 HU, P < 0.05; 56 mm/s: 261 +/- 57 HU, NS) and the fewest noninterpretable arterial segments below the knee were observed with a TF of 48 mm/s (reader 1: 5/121 = 4.1%; reader 2: 4/121 = 3.3%). In patients with AAA, the fewest nondiagnostic segments occurred with a TF of 30 mm/s (2/12 = 17%, both readers) and 40 mm/s (4/24 = 17%, both readers). A TF of 48 mm/s provided the best synchronization of CT data acquisition and contrast bolus propagation and thus the best image quality in patients with PAOD and AI. In patients with AAA, a slower TF of 30 mm/s provided better image quality than faster CT protocols.

[16-row multidetector CT angiography of the aortoiliac system and lower extremity arteries: contrast enhancement and image quality using a standarized examination protocol]. / Becken-Bein-CT-Angiographie mit der 16-Zeilen-Multislice-Technik: Kontrastmittel-Enhancement und Bildqualität unter Einsatz eines standardisierten Untersuchungsprotokolls.

PURPOSE: To assess the degree of enhancement and image quality of 16-slice multidetector CT angiography (MDCTA) of pelvic and lower limb arteries with a monophasic contrast medium injection protocol. MATERIALS AND METHODS: Fifty patients underwent a CT angiography of the pelvic and lower limb arteries using the following parameters: collimation 16 x 1.5 mm, rotation time 0.5 s, table feed 40 mm/sec, slice thickness 2 mm, reconstruction interval 1.2 mm, 100 ml Iomeprol 400 + 60 ml normal saline, flow rate 4 ml/s, bolus tracking (threshold of 250 DeltaHU in aorta). Arterial enhancement was measured in all arterial segments. Maximum intensity projections (MIP) together with axial images were reviewed by two radiologists (consensus). If the results were inconclusive for stenosis, additional curved multiplanar reformations (MPR) were performed. RESULTS: The mean arterial enhancement values were aorta: 314 +/- 69, pelvis: 342 +/- 105, thigh: 347 +/- 139, calf: 231 +/- 109 DeltaHU. The image quality was judged as excellent in 346 (77.6 %), adequate in 76 (17 %), and inadequate in 24 (5.4 %, all but one in calf and foot) of 446 arterial territories. An override of the contrast bolus below the knee occurred in 2 patients rendering the calf arteries nondiagnostic. Venous enhancement occurred in 13 patients but this compromised the diagnostic assessment in only one case. Additional MPRs were required accurately to assess stenoses in 22 of 200 arterial levels in 16 patients with marked arterial calcifications. CONCLUSION: 16-slice MDCTA with a monophasic contrast bolus of Iomeprol 400 provided good arterial enhancement and diagnostic image quality in 94.6 % of the depicted arterial segments. The majority (67 %) of nondiagnostic segments were below the ankle. MPRs were required in patients with marked calcification for accurate assessment of stenosis.