RESUMO
The aim of this study was to evaluate the effects of topical application of simvastatin gel (7.5 mg) on the removal torque of titanium implants in the rabbit tibia. A total of 32 surgeries were performed on 16 New Zealand rabbits for the placement of 2 implants in 1 tibia of each rabbit. Only 1 of the surgical defects was injected with 30 mg/mL of simvastatin gel before implant placement. The initial torque was set at 20 N.cm, and removal torque testing was performed 28 and 56 days postoperatively with a Tonishi torque wrench. Surgical defects were divided into 4 groups: group IG-28 (test, 28 days), group IG-56 (test, 56 days), group I-28 (control, 28 days), and group I-56 (control, 56 days). Removal torque values were higher in group IG-56 than in groups IG-28, I-28, and I-56 (P < .05). Groups IG-28, I-28, and I-56 showed similar values (P > .05). Removal torque force increased under the influence of simvastatin, indicating that topical administration of a 7.5-mg dose of simvastatin gel is effective in improving the torque force required to remove implants inserted in the rabbit tibia.
Assuntos
Conservadores da Densidade Óssea/farmacologia , Implantes Dentários , Remoção de Dispositivo , Inibidores de Hidroximetilglutaril-CoA Redutases/farmacologia , Sinvastatina/farmacologia , Tíbia/cirurgia , Condicionamento Ácido do Dente/métodos , Administração Tópica , Animais , Corrosão Dentária/métodos , Materiais Dentários/química , Planejamento de Prótese Dentária , Géis , Inibidores de Hidroximetilglutaril-CoA Redutases/administração & dosagem , Masculino , Coelhos , Sinvastatina/administração & dosagem , Propriedades de Superfície , Tíbia/efeitos dos fármacos , Fatores de Tempo , Titânio/química , TorqueRESUMO
O objetivo deste estudo foi avaliar a influência do gel de sinvastatina tópico no destorque de implantes instalados em tíbias de coelhos. Foram realizadas 32 cirurgias em 16 coelhos New Zealand para instalação de dois implantes em uma de suas tíbias. Um dos alvéolos foi previamente preenchido com o gel de estatina 30 mg/ml. O torque inicial foi de 20 Ncm e o destorque foi avaliado aos 28 e 56 dias com torquímetro Tohnichi. Os alvéolos cirúrgicos foram divididos em grupo IG -28 (teste - 28 dias): oito implantes + gel - 28 dias (IG-28); grupo IG-56 (teste - 56 dias): oito implantes + estatina - 56 dias (IG-56); grupo I-28 (controle - 28 dias): oito implantes - 28 dias (I-28); grupo I-56 (controle 56 dias): oito implantes - 56 dias (I-56). Valores do grupo IG-56 foram maiores que os grupos IG-28, I-28 e I-56 (p < 0,05). O gel de estatina aumentou a força de destorque no grupo IG-56 (teste 56 dias).
The aim of this study was to evaluate the influence of topical simvastatin application on implant removal torque values using a rabbit tibia model. Thirty-two surgeries were performed on 16 New Zealand rabbits for installation of two implants. One of the alveolus was first filled with the 30 mg/ml of simvastatin gel. The initial torque was 20 Ncm and removal torque was evaluated at 28 and 56 days with a Tohnichi torque wrench. The alveoli were divided into surgical Group IG-28: eight implants + simvastatin - 28 days, group IG-56 (test 56 days): eight implants + simvastatin - 56 days, group I-28 (control - 28 days): eight implants - 28 days, group I-56 (control 56 days): eight implants - 56 days. Mean values of group IG-56 were higher than groups IG-28, I-28 and I-56 (p < 0.05). Groups IG-28, I-28 and I-56 were similar (p > 0.05). The simvastatin gel increased torque removal values in group IG-56 (test - 56 days).
