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J Pharm Biomed Anal ; 23(2-3): 591-5, 2000 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-10933553

RESUMO

The mucolitic bromhexine [N-(2-amino-3,5-dibromobenzyl)-N-methylcyclohexylamine] has been determined in cotrimoxazole-containing tablets by partial least-squares (PLS-1) multivariate of spectrophotometric calibration data in the spectral range 310-350 nm. In the studied commercial tablets, cotrimoxazole is present in large excess (ca. 100:1 in weight) with respect to bromhexine, and a high degree of spectral overlapping exists among bromhexine and cotrimoxazole components. However, the obtained recoveries are reasonably good with the presently discussed technique.


Assuntos
Bromoexina/análise , Análise dos Mínimos Quadrados , Espectrofotometria Atômica/métodos , Comprimidos/análise , Combinação Trimetoprima e Sulfametoxazol/análise , Calibragem
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