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1.
Arthrosc Sports Med Rehabil ; 6(2): 100886, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-38328528

RESUMO

Purpose: To determine whether there was a relationship between sleep position and symptomatic partial- and full-thickness rotator cuff tears. Methods: A consecutive series of patients that met the inclusion/exclusion criteria (n = 58) were in seen in clinic between July 2019 and December 2019. All of these individuals had a significant partial-thickness (> 50%) or full-thickness rotator cuff tear determined by either ultrasound, magnetic resonance imaging, or both. All patients in this series either had an insidious onset of shoulder pain or their symptoms were related to the basic wear and tear of daily activities. Traumatic rotator cuff tears (those associated with a significant traumatic event such as shoulder instability, motor vehicle accidents, sports related injuries, etc.) were excluded. Previous shoulder surgery, recurrent rotator cuff tears, and worker's compensation cases also were excluded from this series. As part of the history-taking process, the patients were asked what was their preferred sleeping position-side sleeper, back sleeper, or stomach sleeper. A χ2 test was conducted to determine the relationship between rotator cuff pathology and sleep position. Results: Of the 58 subjects, 52 of the patients were side sleepers, 4 were stomach sleepers, 1 was a back sleeper, and 1 preferred all 3 positions. Statistical analysis, using the χ2 test (P < .0001), demonstrated that rotator cuff tears were most often seen in side sleepers. Conclusions: In our study, there appeared to be a relationship between the preference of being a side sleeper and the presence of a rotator cuff tear. Level of Evidence: Level IV, prognostic case series.

2.
Molecules ; 27(20)2022 Oct 20.
Artigo em Inglês | MEDLINE | ID: mdl-36296666

RESUMO

Ladybird beetles (Coleoptera: Coccinellidae) possess strong chemical defences that are secreted in response to stress and are also found on the coating of eggs, which are rich in alkaloids that are responsible for their toxicity to other species. Recent studies have shown that alkaloids from several species of ladybird beetle can target nicotinic acetylcholine receptors (nAChRs) acting as receptor antagonists. Here, we have explored the actions of (-)-adaline, found in the 2-spot (Adalia bipunctata) and 10-spot (Adalia decempunctata) ladybirds, on both mammalian (α1ß1γδ, α7, α4ß2, α3ß4) and insect nAChRs using patch-clamp of TE671 cells and locust brain neurons natively expressing nAChRs, as well as two-electrode voltage clamp of Xenopus laevis oocytes recombinantly expressing nAChRs. All nAChR subtypes were antagonised by (-)-adaline in a time-dependent, voltage-dependent and non-competitive manner with the lowest IC50s at rat α3ß4 (0.10 µM) and locust neuron (1.28 µM) nAChRs, at a holding potential of -75 mV. The data imply that (-)-adaline acts as an open channel blocker of nAChRs.


Assuntos
Alcaloides , Besouros , Receptores Nicotínicos , Animais , Ratos , Piperidinas , Antagonistas Nicotínicos , Xenopus laevis , Mamíferos
3.
Molecules ; 26(22)2021 Nov 19.
Artigo em Inglês | MEDLINE | ID: mdl-34834099

RESUMO

Alterations in the polyamine and amino acid (tyrosine) moieties of philanthotoxin-343 (PhTX-343) were investigated for their effects on the antagonism of nicotinic acetylcholine receptors (nAChRs) isolated from the locust (Schistocerca gregaria) mushroom body. Through whole-cell patch-clamp recordings, the philanthotoxin analogues in this study were shown to cause inhibition of the inward current when co-applied with acetylcholine (ACh). PhTX-343 (IC50 = 0.80 µM at -75 mV) antagonised locust nAChRs in a use-dependent manner, suggesting that it acts as an open-channel blocker. The analogue in which both the secondary amine functionalities were replaced with methylene groups (i.e., PhTX-12) was ~6-fold more potent (IC50 (half-maximal inhibitory concentration) = 0.13 µM at -75 mV) than PhTX-343. The analogue containing cyclohexylalanine as a substitute for the tyrosine moiety of PhTX-343 (i.e., Cha-PhTX-343) was also more potent (IC50 = 0.44 µM at -75 mV). A combination of both alterations to PhTX-343 generated the most potent analogue, i.e., Cha-PhTX-12 (IC50 = 1.71 nM at -75 mV). Modulation by PhTX-343 and Cha-PhTX-343 fell into two distinct groups, indicating the presence of two pharmacologically distinct nAChR groups in the locust mushroom body. In the first group, all concentrations of PhTX-343 and Cha-PhTX-343 inhibited responses to ACh. In the second group, application of PhTX-343 or Cha-PhTX-343 at concentrations ≤100 nM caused potentiation, while concentrations ≥ 1 µM inhibited responses to ACh. Cha-PhTX-12 may have potential to be developed into insecticidal compounds with a novel mode of action.


Assuntos
Gafanhotos/química , Proteínas de Insetos/química , Antagonistas Nicotínicos/química , Fenóis/química , Poliaminas/química , Receptores Nicotínicos/química , Tirosina/análogos & derivados , Acetilcolina/química , Acetilcolina/metabolismo , Aminoácidos/química , Aminoácidos/metabolismo , Animais , Gafanhotos/metabolismo , Proteínas de Insetos/antagonistas & inibidores , Proteínas de Insetos/metabolismo , Antagonistas Nicotínicos/farmacologia , Fenóis/farmacologia , Poliaminas/farmacologia , Conformação Proteica , Receptores Nicotínicos/metabolismo , Tirosina/química , Tirosina/farmacologia
4.
Pestic Biochem Physiol ; 166: 104561, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32448416

RESUMO

The harlequin ladybird, Harmonia axyridis (H. axyridis), possesses a strong chemical defence that has contributed to its invasive success. Ladybird beetle defensive chemicals, secreted in response to stress and also found on the coating of laid eggs, are rich in alkaloids that are thought to be responsible for this beetle's toxicity to other species. Recent studies have shown that alkaloids from several species of ladybird beetle can target nicotinic acetylcholine receptors (nAChRs) acting as receptor antagonists, hence we have explored the actions of alkaloids of the ladybird H. axyridis on both mammalian and insect nAChRs. Electrophysiological studies on native and functionally expressed recombinant nAChRs were used to establish whether an alkaloid extract from H. axyridis (HAE) targeted nAChRs and whether any selectivity exists for insect over mammalian receptors of this type. HAE was found to be an inhibitor of all nAChRs tested with the voltage-dependence of inhibition and the effect on ACh EC50 differing between nAChR subtypes. Our finding that an HAE fraction consisting almost entirely of harmonine had a strong inhibitory effect points to this alkaloid as a key component of nAChR inhibitory actions. Comparison of HAE inhibition between the mammalian and insect nAChRs investigated indicates some preference for the insect nAChR supporting the view that investigation of ladybird alkaloids shows promise as a method for identifying natural product leads for future insecticide development.


Assuntos
Alcaloides , Besouros , Receptores Nicotínicos , Alcenos , Animais , Extratos Vegetais
5.
Orthopedics ; 31(4): 347-50, 2008 04.
Artigo em Inglês | MEDLINE | ID: mdl-18453170

RESUMO

This study examined the forces during motion across human meniscal tears. Longitudinal cuts were created in 6 human cadaveric knees at the red-white junction of the medial and lateral menisci into which a pressure transducer was placed. Pressure data were gathered with the knees at neutral, internal rotation, and external rotation and matched to knee flexion. The meniscal cuts were compressed throughout the range of motion. No distraction pressures were observed. Therefore, meniscal tear displacement does not occur with knee motion and a meniscal repair device load-to-failure strength may be less important than the device's ability to accurately reduce a meniscal tear and avoid shear stress.


Assuntos
Traumatismos do Joelho/fisiopatologia , Amplitude de Movimento Articular/fisiologia , Lesões do Menisco Tibial , Idoso , Artroscopia , Fenômenos Biomecânicos , Cadáver , Feminino , Humanos , Traumatismos do Joelho/patologia , Masculino , Meniscos Tibiais/patologia , Meniscos Tibiais/fisiopatologia , Pessoa de Meia-Idade , Ruptura
6.
Arthroscopy ; 23(10): 1033-41, 2007 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-17916467

RESUMO

PURPOSE: The purpose of this study was to analyze the results of the modified Latarjet procedure for shoulder instability associated with an inverted-pear glenoid (bone loss of at least 25% of the width of the inferior glenoid) or an engaging Hill-Sachs lesion. METHODS: From March 1996 to December 2002, 102 patients underwent an open Latarjet procedure for shoulder instability with an inverted-pear glenoid, with or without an associated engaging Hill-Sachs lesion, by the 2 senior authors (S.S.B. and J.F.D.), and 47 of them were available for follow-up physical examination. The remaining 55 patients were contacted by telephone or letter to see if they had had recurrent dislocation or subluxation. The mean age of the patients was 26.5 +/- 6.6 years (range, 16 to 41 years). There were 46 male patients and 1 female patient. Preoperatively, mean forward elevation was 177.2 degrees +/- 13.6 degrees (range, 90 degrees to 180 degrees) and mean external rotation with the arm at the side was 55.3 degrees +/- 16.1 degrees (range, 0 degrees to 80 degrees). All patients had a positive apprehension sign preoperatively. The median number of dislocations before surgery was 6, with 20 patients having had more than 15 dislocations preoperatively. RESULTS: The mean follow-up time for the 47 patients who were personally examined was 59.0 +/- 18.5 months (range, 32 to 108 months). Postoperatively, mean forward elevation was 179.6 degrees +/- 2.0 degrees (range, 170 degrees to 180 degrees; gain of 2.4 degrees) and external rotation with the arm at the side was 50.2 degrees +/- 12.6 degrees (range, 22 degrees to 78 degrees; loss of 5.1 degrees). As for postoperative functional scores, the mean Constant score was 94.4 and the mean Walch-Duplay score was 91.7. None of these 47 patients showed any further dislocation, and 1 of them still had a positive apprehension sign (2.2%) indicating subluxation. However, 4 patients out of the total 102 who underwent the modified Latarjet procedure had a recurrence. With 4 recurrent dislocations and 1 recurrent subluxation, there was a 4.9% recurrence rate. The 4 patients with recurrent dislocations were not among the 47 who returned for personal follow-up evaluation. CONCLUSIONS: The 2 senior authors (S.S.B. and J.F.D.) have previously reported an unacceptably high recurrence rate (67%) for arthroscopic Bankart repair in the presence of an inverted-pear glenoid with or without an engaging Hill-Sachs lesion. They have recommended an open modified Latarjet procedure in such patients. The present study confirms the validity of that recommendation, because the same 2 surgeons have had only a 4.9% recurrence rate in that same category of patient at a mean follow-up of 59 months. Furthermore, the results of this study show the efficacy of the modified Latarjet procedure in the extremely challenging category of patients who present with such dramatic bone loss that soft-tissue reconstruction, either open or arthroscopic, is not a reasonable option. LEVEL OF EVIDENCE: Level IV, therapeutic case series.


Assuntos
Artroscopia , Procedimentos Ortopédicos/métodos , Luxação do Ombro/cirurgia , Articulação do Ombro/patologia , Traumatismos em Atletas/cirurgia , Transplante Ósseo , Feminino , Humanos , Masculino , Recidiva , Luxação do Ombro/patologia , Articulação do Ombro/cirurgia
7.
Arthroscopy ; 23(9): 1019-22, 2007 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-17868843

RESUMO

Osteoarthritis of the glenohumeral joint in younger, active patients presents a difficult situation to the surgeon, who would like to delay the necessity for hemiarthroplasty or total shoulder replacement until the patient is older and less active. This report outlines our technique of arthroscopic debridement and capsular release. By using electrocautery to release the rotator interval, anterior capsule, posterior capsule, and axillary recess, we have been able to improve the range of motion and to achieve pain relief. In 8 patients the mean improvement in range of motion was as follows: forward elevation, 21.4 degrees ; external rotation, 16.6 degrees; and internal rotation, 31.1 degrees. We believe that a reduction in joint contact pressures through a greater range of motion is the primary mechanism for pain relief resulting from capsular release.


Assuntos
Osteoartrite/cirurgia , Articulação do Ombro/cirurgia , Adulto , Idoso , Desbridamento , Humanos , Cápsula Articular/cirurgia , Masculino , Pessoa de Meia-Idade , Amplitude de Movimento Articular
8.
Arthroscopy ; 23(4): 347-54, 2007 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-17418325

RESUMO

PURPOSE: The purpose of this study was to assess the functional results of arthroscopic repair of massive rotator cuff tears in patients who had stage 3 and 4 fatty degeneration of the rotator cuff musculature, according to the Goutallier scale. METHODS: From January 1997 to December 2001, 22 patients with massive rotator cuff tears and Goutallier stage 3 or 4 fatty degeneration of the infraspinatus, with a mean age of 66.5 +/- 9.26 years, underwent arthroscopic rotator cuff repair and were available for follow-up. The average tear size was 4.8 +/- 0.85 cm in medial-to-lateral width and 6.2 +/- 1.53 cm in anterior-to-posterior length, with an approximate tear size area of 30.0 +/- 10.0 sq cm, and involved 2 tendons (supraspinatus and infraspinatus) or 3 tendons (supraspinatus, infraspinatus, and subscapularis) in each case. The mean time from surgery to follow-up was 39.3 months (range, 24-60 months). In addition to comparison of preoperative and postoperative range of motion, strength and University of California, Los Angeles (UCLA) score, outcomes were also assessed with the Constant score. RESULTS: The increase of mean active forward elevation was 53.7 degrees (preoperative: 103.2 degrees and postoperatively: 156.9 degrees ). The gain of mean active external rotation was 19.1 degrees (preoperative: 35.7 degrees and postoperative: 54.8 degrees). The gain of mean external rotation power was 1.9 (preoperative: 2.3 and postoperative: 4.2). The improvement in the UCLA score was 17.2 points (preoperative: 12.3 and postoperative: 29.5). The mean postoperative Constant score was 74.8/100, and the weighted postoperative Constant score was 88.5/100. In 5 patients with fatty degeneration greater than 75% (advanced stage 4), results were less dramatically improved than in 17 patients with fatty degeneration of 50% to 75%, all of whom exhibited clinical improvement. However, clinical improvement was achieved even in 2 of 5 patients with advanced stage 4 involvement. CONCLUSIONS: Arthroscopic rotator cuff repair in patients with grade 3 or 4 fatty degeneration (> or =50%) can provide significant functional improvement. Those with 50% to 75% fatty degeneration showed a much greater degree of improvement (with all 17 cases exhibiting beneficial postoperative increases in their UCLA scores ranging from 12 to 26 points) than those with >75% fatty degeneration (with only 2 of 5 cases showing an increase of 10 or more points in their UCLA scores). However, clinical improvement was observed in 86.4% of cases that would have been classified as likely to fail by the Goutallier criteria. LEVEL OF EVIDENCE: Level IV, therapeutic case series.


Assuntos
Tecido Adiposo/patologia , Artroscopia/métodos , Lesões do Manguito Rotador , Traumatismos dos Tendões/cirurgia , Idoso , Estudos de Coortes , Feminino , Seguimentos , Humanos , Escala de Gravidade do Ferimento , Masculino , Pessoa de Meia-Idade , Medição da Dor , Amplitude de Movimento Articular , Recuperação de Função Fisiológica , Estudos Retrospectivos , Medição de Risco , Dor de Ombro/diagnóstico , Dor de Ombro/etiologia , Traumatismos dos Tendões/diagnóstico
9.
Arthroscopy ; 23(3): 251-4, 2007 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-17349466

RESUMO

PURPOSE: The purpose of this study was to describe the anatomic footprint of the subscapularis tendon. METHODS: We examined 19 cadaveric shoulder specimens in this study. Dissection was carried out to the level of the subscapularis through a deltopectoral approach. The subscapularis tendon was identified, and the dissection was continued, elevating the tendon, subperiosteally, from its insertion site at the lesser tuberosity. The dimensions of the footprint were measured superior to inferior, as well as medial to lateral, by a single observer. RESULTS: The insertion of the subscapularis tendon on the lesser tuberosity was trapezoidal in shape. The mean length of the subscapularis tendon footprint was 2.5 cm (range, 1.5 to 3.0 cm). The superior portion of the footprint was the widest part of the subscapularis insertion. The mean width at the most superior aspect of the insertion site was 1.8 cm (range, 1.5 to 2.6 cm). The most inferior aspect of the footprint was much narrower, with a mean width of 0.3 cm (range, 0.1 to 0.7 cm). CONCLUSIONS: The subscapularis insertion footprint has a broad and wide superior attachment that narrows distally to form a trapezoidal shape. We found the mean length of the footprint to be 2.5 cm. The mean superior width of the footprint was 1.8 cm, which was maintained for the upper 60% of the tendon insertion, at which point the footprint began to rapidly narrow to a minimum width of 0.3 cm at its most inferior aspect. The upper 60% of the footprint provided by far the major surface area for tendon insertion, consistent with prior findings of superior load transmission at the superior aspect of the footprint. CLINICAL RELEVANCE: This broad attachment site superiorly is likely important in load transmission. Knowledge of the shape of the footprint of the subscapularis, with a broad superior attachment, makes it easier for the surgeon to perform an accurate anatomic surgical reconstruction of the torn subscapularis.


Assuntos
Articulação do Ombro , Tendões/anatomia & histologia , Idoso , Idoso de 80 Anos ou mais , Cadáver , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
10.
Sports Med Arthrosc Rev ; 14(3): 177-84, 2006 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-17135965

RESUMO

Arthroscopic surgery requires appropriate surgical implants for effective fixation of tendons and ligaments to bone. Biodegradable suture anchors are being used with increasing frequency for various procedures in sports medicine. As companions to these biodegradable suture anchors, new sutures have been developed which possess greater strength and different material properties from the conventional braided polyester suture. Biodegradable polymers currently found in sutures and suture anchors include poly-L-lactic acid, poly-D, L lactic acid, polydioxanone, polyglycolic acid and their copolymers. Suture anchors are now available preloaded with a choice of conventional braided polyester sutures or some version of ultrahigh molecular weight polyethylene ("super") sutures. Most new suture anchors come with 2 sutures. The manner in which these sutures are attached to the anchor varies and may consist of 2 separate eyelets or 2 slots either parallel to one another or at different angles to one another. Some anchors have a very large single eyelet that allows for 2 or more sutures.


Assuntos
Artroscopia , Suturas , Materiais Biocompatíveis , Fenômenos Biomecânicos , Humanos , Medicina Esportiva , Suturas/tendências
11.
Arthroscopy ; 21(12): 1428, 2005 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-16376230

RESUMO

PURPOSE: To determine the magnetic resonance imaging (MRI) criteria for predicting rotator cuff tear pattern and method of repair. TYPE OF STUDY: Retrospective MRI/arthroscopy correlation. METHODS: Sixty-six preoperative MRI scans were evaluated. The maximum medial to lateral length (L) of the tear was measured on T2-weighted coronal cuts. The maximum anterior to posterior width (W) was measured on T2-weighted sagittal cuts. The cases were divided into 3 groups: group 1, short-wide tears, L < or = W, L < 2 cm; group 2, long-narrow tears, L > W, W < 2 cm; and group 3, long-wide tears, L > or = 2 cm, W > or = 2 cm. RESULTS: Of the 66 MRI scans, 55 were adequate for standardized measurement. Group 1, 16 cases: 15 were found at arthroscopy to be crescent-shaped tears repaired end-to-bone; 1 was repaired with interval slides. Group 2, 22 cases: all 22 were repaired side-to-side/margin convergence. Group 3, 17 cases: 12 required interval slides, 1 partial repair was performed, and 4 were repaired side-to-side/margin convergence. CONCLUSIONS: Tear pattern and method of repair can be predicted on high-quality MRI scan. Group 1, L < or = W and L < 2 cm, predicts a crescent-shaped tear and end-to-bone repair (positive predictive value, 93.8%). Group 2, L > W and W < 2 cm, predicts a longitudinal tear and side-to-side/margin convergence repair (positive predictive value 100%). Group 3, L > or = 2 cm and W > or = 2 cm, predicts a massive contracted tear and that primary end-to-bone or side-to-side repairs are usually not possible and that interval slides or partial repair may be necessary (positive predictive value, 76.5%). The overall diagnostic model based on usable MRI scans significantly predicted arthroscopic findings (P < .001 for chi-square test). LEVEL OF EVIDENCE: Level III, development of diagnostic criteria with universally applied reference (nonconsecutive patients).


Assuntos
Artroscopia , Imageamento por Ressonância Magnética , Cuidados Pré-Operatórios/métodos , Lesões do Manguito Rotador , Adulto , Idoso , Antropometria/métodos , Feminino , Humanos , Imageamento por Ressonância Magnética/métodos , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Estudos Retrospectivos , Manguito Rotador/patologia , Manguito Rotador/cirurgia
12.
Arthroscopy ; 21(12): 1452-6, 2005 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-16376234

RESUMO

PURPOSE: To determine the displacement forces across a lateral meniscal tear during motion. TYPE OF STUDY: Experimental laboratory biomechanical study. METHODS: A middle third longitudinal lateral meniscal cut was created arthroscopically at the "red-white" junction in 5 intact porcine knees. With a pressure transducer in the tear, the knees were repeatedly cycled through a full range of motion. Pressure data were gathered with the knees held at neutral, internal rotation (IRot), and external rotation (ERot) and matched to the specific flexion angle measured by electronic goniometer. Averaged pressure measurements were calculated at each 5 degrees interval. RESULTS: The highest pressures were seen at full extension (neutral, 589 mm Hg; IRot, 1,110 mm Hg; ERot, 337 mm Hg) and declined to a low at 90 degrees of flexion (neutral, 133 mm Hg; IRot, 314 mm Hg; ERot, 187 mm Hg). Then the pressures increased steadily after 100 degrees as the knees were further flexed. The highest pressure was always seen with IRot. IRot during flexion resulted in higher lateral meniscus compressive loads than ERot. CONCLUSIONS: This model demonstrated that a middle third longitudinal lateral meniscal cut is compressed throughout the full range of knee motion. At no time were negative intrameniscal tear pressures registered that would suggest meniscal cut separation. CLINICAL RELEVANCE: These data suggest that meniscal compressive loads, not distractive loads, occur throughout knee flexion and extension. The absence of distractive loads across a meniscal cut suggests that the ability of a repair to align the meniscal fragment may be more important than a high load to failure strength.


Assuntos
Lesões do Menisco Tibial , Suporte de Carga , Animais , Fenômenos Biomecânicos , Força Compressiva , Meniscos Tibiais/fisiopatologia , Pressão , Amplitude de Movimento Articular , Sus scrofa
13.
Arthroscopy ; 21(10): 1223-8, 2005 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-16226651

RESUMO

PURPOSE: To determine whether coracohumeral distance was significantly narrowed in the presence of a torn subscapularis. TYPE OF STUDY: Retrospective cohort study. METHODS: The coracohumeral distance of a consecutive series of patients (n = 35, 36 shoulders) requiring an arthroscopic repair of the subscapularis was compared with a control group (n = 35). The control group consisted of patients who underwent shoulder arthroscopy but who did not have any rotator cuff, subscapularis, or subcoracoid pathology. The coracohumeral distance was measured from the tip of the coracoid to the cortex of the proximal humerus on an axial cut of preoperative magnetic resonance imaging. A Student t test was used to determine the statistical differences between the 2 groups. RESULTS: The average coracohumeral distance in the subscapularis group was 5.0 +/- 1.7 mm and the average coracohumeral distance in the control group was 10.0 +/- 1.3 mm. Statistical analysis, using the Student t test, showed that the coracohumeral distance was significantly narrowed in the group of patients with a torn subscapularis. CONCLUSIONS: These results show a significant relationship between a narrowed coracohumeral distance and subscapularis pathology. LEVEL OF EVIDENCE: Level III, retrospective cohort study.


Assuntos
Antropometria , Úmero/patologia , Músculo Esquelético/lesões , Escápula/patologia , Traumatismos dos Tendões , Idoso , Artroscopia , Fenômenos Biomecânicos , Estudos de Coortes , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Manguito Rotador/patologia , Lesões do Manguito Rotador , Síndrome de Colisão do Ombro/patologia
14.
Arthroscopy ; 21(7): 861-6, 2005 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-16012500

RESUMO

PURPOSE: To assess and compare the biomechanical properties and load-to-failure of 2 biceps tenodesis fixation techniques, interference screw fixation and double suture anchor fixation. TYPE OF STUDY: Biomechanical study. METHODS: Eleven fresh-frozen human cadaveric specimens were used in this study. A biceps tenodesis was performed using 1 of 2 techniques, interference screw fixation or double suture anchor fixation. A 7-mm interference screw was used in 5 cadaveric trials. A double suture anchor technique was performed in 6 cadaveric specimens. The tenodesis construct in each specimen was loaded to failure using a Servohydraulic materials test system (MTS Model 858; Bionix, MTS Corp, Minneapolis, MN). Each specimen was loaded at 5 mm/second with a preload of 5 N with the vector of pull distally in line with the long axis of the humerus. Each specimen was then loaded until failure of the repair occurred. Statistical analysis of the interference screw group compared with the suture anchor group was performed using a Student t test. RESULTS: The mode of failure of the interference screw group was variable, but the suture anchor group consistently failed at the anchor or anchor eyelet. The average pullout strength of the suture anchor group was 135.5 +/- 37.8 N whereas the failure load in the interference group was 233.5 +/- 55.5 N. The interference group had a significantly greater resistance to pullout than the suture anchor group (P = .007). CONCLUSIONS: Based on these results, a biceps tenodesis using an interference screw will provide greater fixation strength than a biceps tenodesis performed with a double suture anchor technique. CLINICAL RELEVANCE: The surgeon treating biceps tenodesis may wish to choose a fixation technique with higher initial strength (interference screw instead of double suture anchor) to lessen the chance of early failure, particularly if the patient begins early active elbow flexion.


Assuntos
Parafusos Ósseos , Músculo Esquelético/cirurgia , Tendões/cirurgia , Adulto , Fenômenos Biomecânicos , Cadáver , Humanos , Teste de Materiais , Pessoa de Meia-Idade , Procedimentos Ortopédicos/métodos , Resistência ao Cisalhamento , Tendões/anatomia & histologia , Suporte de Carga
15.
Arthroscopy ; 20(7): 771-5, 2004 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-15346121

RESUMO

Massive rotator cuff tears can often be repaired arthroscopically with satisfactory results. Tear pattern recognition, knot security, and loop security are essential in the repair of large and massive rotator cuff tears. In the case of a massive U-shaped tear, with a contracted immobile supraspinatus and a deficient rotator interval, a type of margin convergence technique can be used. This technique allows for the partial closure of the rotator cuff defect along with the proximal advancement of the posterior cuff by securing the posterior leaf of the cuff tendon to the tendon of the long head of the biceps brachii. Because of the mechanical effect of strain reduction in margin convergence, this procedure decreases the strain at the margin of the posterior cuff, thereby protecting its repair to bone. Our goal with this procedure is not to obtain healing of the cuff to the biceps, but to optimize the conditions for healing of the rotator cuff to bone.


Assuntos
Artroscopia/métodos , Manguito Rotador/cirurgia , Tendões/cirurgia , Humanos , Úmero , Manguito Rotador/patologia , Lesões do Manguito Rotador , Técnicas de Sutura , Tendões/patologia , Resultado do Tratamento , Cicatrização
16.
Arthroscopy ; 20 Suppl 2: 201-7, 2004 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-15243459

RESUMO

A number of open procedures have been presented in the literature that described the repair of the ruptured long head of biceps brachii (LHBB). Although arthroscopic biceps tenodesis techniques have been used to address partial tears or subluxation of the biceps, no arthroscopic technique to assist in the treatment of complete retracted ruptures of the LHBB has been described. This article describes an arthroscopic-assisted biceps tenodesis, using interference screw fixation, in the treatment of acute or chronic LHBB ruptures. An arthroscopic-assisted biceps tenodesis with interference screw fixation provides an alternative to open LHBB tenodesis. The ability to tenodese the retracted LHBB arthroscopically is a technologic advance that could reduce morbidity in comparison to open tenodesis, thus resulting in a better functional outcome.


Assuntos
Artroscopia/métodos , Lesões no Cotovelo , Articulação do Cotovelo/cirurgia , Músculo Esquelético/lesões , Músculo Esquelético/cirurgia , Traumatismos dos Tendões , Tendões/cirurgia , Implantes Absorvíveis , Parafusos Ósseos , Humanos , Ruptura , Técnicas de Sutura
17.
Arthroscopy ; 20(6): 614-9, 2004 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-15241313

RESUMO

PURPOSE: The purpose of this study was to determine whether a relationship existed between primary adhesive capsulitis and acromial morphology. TYPE OF STUDY: Case control series. METHODS: Between January 1999 and June 2002, a total of 100 patients (104 shoulders) were diagnosed with adhesive capsulitis. A retrospective chart review was performed of all of these patients. A total of 67 patients (69 shoulders) met the inclusion criteria of primary adhesive capsulitis. The patients' range of motion and signs of impingement were documented. The supraspinatus outlet radiographs were assessed, and each patient's acromial morphology was graded as type I, II, or III. A case control group of 53 patients (58 shoulders) was assessed to determine the validity of our results. This group consisted of a series of new patients that were referred to the clinic during February 2003 for assessment of their shoulders. RESULTS: The average age of the patients in the adhesive capsulitis group was 52.5 +/- 7.6 years, with 34 women (50.7%) and 33 men (49.3%). The control group had an average age of 51.1 +/- 16.9 years in a series of 19 (35.8%) women and 34 (64.2%) men. The average range of motion was 98.0 degrees +/- 23.5 degrees of forward elevation, and 91.9 degrees +/- 24.3 degrees of abduction. The forward elevation was 165.5 degrees +/- 15.3 degrees and the abduction was 162.4 degrees +/- 18.4 degrees. The predominant acromial morphology in both groups in this study was a type II acromion (75.4% in the adhesive capsulitis group and 74.1% in the control group). The chi-square analysis within the specific groups showed statistically significant differences in the number of type II compared with type I acromions, and type II compared with type III acromions in both series. However, statistical analysis showed no significant difference between the various acromial types when comparing the adhesive capsulitis group with the control group. CONCLUSIONS: Our results show a significant number of patients with both adhesive capsulitis and, in the control group, type II acromions. We found no statistical difference between these 2 groups. Based on our results, the intrinsic trauma that occurs from subacromial space narrowing caused by the anterior acromial shape, cannot be implicated as the cause of primary adhesive capsulitis. LEVEL OF EVIDENCE: Level III, case control study.


Assuntos
Acrômio/diagnóstico por imagem , Bursite/diagnóstico por imagem , Acrômio/ultraestrutura , Idoso , Antropometria , Estudos de Casos e Controles , Suscetibilidade a Doenças , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Radiografia , Amplitude de Movimento Articular , Estudos Retrospectivos
18.
Arthroscopy ; 20 Suppl 2: 134-41, 2004 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-15243447

RESUMO

Humeral avulsion of the glenohumeral ligaments (HAGL lesion) is one of the pathologic lesions that occurs secondary to anterior glenohumeral instability. Although HAGL lesions occur less commonly than Bankart lesions in cases of anterior instability, it is necessary to understand this pathology and to make the necessary repair. An all-arthroscopic technique using suture anchors can be used to repair HAGL lesions, but it is a difficult and demanding technique. To facilitate this type of repair, the surgeon must be: (1) comfortable with both the 30 degrees and 70 degrees arthroscopes, (2) able to establish and use the 5-o'clock portal, (3) able to abduct and externally rotate the arm, and (4) able to ensure secure fixation of the glenohumeral ligaments to bone through adequate knot and loop security.


Assuntos
Artroscopia/métodos , Instabilidade Articular/complicações , Instabilidade Articular/cirurgia , Ligamentos Articulares/lesões , Ligamentos Articulares/cirurgia , Articulação do Ombro/cirurgia , Doença Aguda , Adulto , Idoso , Parafusos Ósseos , Doença Crônica , Feminino , Humanos , Lacerações/etiologia , Lacerações/cirurgia , Masculino , Recidiva , Manguito Rotador/cirurgia , Lesões do Manguito Rotador , Lesões do Ombro , Técnicas de Sutura
19.
Arthroscopy ; 20(1): 45-50, 2004 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-14716278

RESUMO

PURPOSE: New all-inside meniscal repair devices include those combining sutures with anchors and that allow for an "adjustable" repair. This study's purpose was to compare the failure strength of new meniscal repair devices with suture repairs. TYPE OF STUDY: Experimental laboratory biomechanical study. METHODS: A single repair was placed in a vertical longitudinal peripheral tear made in fresh adult porcine menisci. Group 1 had a vertically oriented suture using the FasT-Fix (Smith & Nephew Endoscopy, Andover, MA) device. Group 2 had a horizontally oriented mattress suture using the FasT-Fix device. Group 3 had a repair using 2 Arthrex (Naples, FL) meniscal darts. The Group 4 repair used a RapidLoc (Mitek Surgical Products, Westwood, MA) device. The Group 5 repair used the Arthrotek meniscal screw (Biomet, Warsaw, IN). Group 6 had a single vertical suture, and group 7 a single horizontal suture, both of 2-0 Mersilene (Ethicon, Somerville, NJ). Load to failure testing was performed. RESULTS: The vertical FasT-Fix suture had a mean load to failure of 70.9 N (1 SD +/- 33). The horizontal FasT-Fix suture had a mean load to failure of 72.1 N (+/- 23.5). The double Dart repair had a mean load to failure of 61.7 N (+/- 19). The RapidLoc repair had a mean load to failure of 43.28 N (+/- 3.98). The Arthrotek meniscal screw repair had a mean load to failure of 28.09 N (+/- 7.93). Failure occurred with device pullout of the inner rim (9 of 10) for the Darts, device pullout of the inner rim (6 of 10) and pullout of the outer rim (4 of 10) for the Arthrotek screw, and suture breakage for the FasT-Fix and the RapidLoc devices. The vertical sutures' mean load to failure was 80.43 N (+/- 8.5), and all 13 failed by suture breaking. The horizontal sutures' mean failure load was 55.9 N (+/- 18.8), and failure was by both suture breaking (6 of 10) and pulling through the meniscal tissue (4 of 10). CONCLUSIONS: Some of the newer meniscal repair devices show improved loads to failure over earlier generations.


Assuntos
Análise de Falha de Equipamento/métodos , Meniscos Tibiais/cirurgia , Dispositivos de Fixação Ortopédica , Animais , Desenho de Equipamento , Técnicas In Vitro , Técnicas de Sutura , Suínos , Lesões do Menisco Tibial , Suporte de Carga
20.
Arthroscopy ; 19(9): 985-90, 2003 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-14608318

RESUMO

PURPOSE: The purpose of this study was to evaluate recently introduced sutures and suture anchors for single-pull load-to-failure strength and failure mode. TYPE OF STUDY: Experimental laboratory biomechanical study. METHODS: Using an established protocol in fresh porcine femurs, anchors were tested in diaphyseal cortex, metaphyseal cortex, and cancellous troughs after threading them with either steel sutures or strong synthetic material to reduce the likelihood of suture breakage as a mode of failure. An Instron machine (Instron, Canton, MA) applied tensile loads parallel to the axis of insertion at a rate of 12.5 mm/second until failure, and mean anchor failure strengths were calculated. Mode of failure was recorded (anchor pullout, suture eyelet cutout, or wire breakage). Anchors tested included the RotorloC (Smith & Nephew Endoscopy, Andover, MA), TwinFix Ti 3.5, TwinFix Ti 5.0, and TwinFix AB (Smith & Nephew Endoscopy), Super Revo and UltraSorb (Linvatec, Largo, FL), Duet (Bionx Implants, Blue Bell, PA), AlloAnchor RC (Regeneration Technologies, Alachua, FL), Opus Magnum anchor (Opus Medical, San Juan Capistrano, CA), and the BioCorkscrew 5.0 and BioCorkscrew 6.5 (Arthrex, Naples, FL). Sutures tested were No.2 and No. 5 Ethibond (Ethicon, Somerville, NJ), No. 2 Panacryl (Mitek, a division of Ethicon, Somerville, NJ), and Nos. 2, 5, and 2-0 Fiberwire (Arthrex, Naples, FL). RESULTS: The sutures all broke in the midpoint of their tested strand away from the grips. The No. 2 Ethibond failed at a mean of 21 lb (92 N); No. 5 Ethibond failed at a mean of 44 lb (193 N); No. 2, No. 5, and No. 2-0 Fiberwire at means of 44 lb (188 N), 112 lb (483N), and 19 lb (82 N), respectively; and No. 2 Panacryl at a mean of 22 lb (99 N). The suture anchors all failed at levels higher than the associated sutures. CONCLUSIONS: Screw anchors showed higher load to failure values than nonscrew designs, and the new biodegradable anchors showed failure loads lower than the anchors. All anchors were stronger than the suture for which they are designed.


Assuntos
Implantes Experimentais , Técnicas de Sutura , Animais , Parafusos Ósseos , Análise de Falha de Equipamento , Fêmur , Teste de Materiais , Nylons , Polietilenotereftalatos , Aço Inoxidável , Técnicas de Sutura/instrumentação , Suínos , Resistência à Tração
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