RESUMO
The aMAZE LightBench (http://www.amaze.ulb. ac.be/) is a web interface to the aMAZE relational database, which contains information on gene expression, catalysed chemical reactions, regulatory interactions, protein assembly, as well as metabolic and signal transduction pathways. It allows the user to browse the information in an intuitive way, which also reflects the underlying data model. Moreover links are provided to literature references, and whenever appropriate, to external databases.
Assuntos
Fenômenos Fisiológicos Celulares , Bases de Dados Factuais , Internet , Biologia Molecular , Interface Usuário-Computador , Fenômenos Bioquímicos , Bioquímica , Biologia Computacional , Regulação da Expressão Gênica , Armazenamento e Recuperação da Informação , Metabolismo , Ligação Proteica , Transdução de SinaisRESUMO
MOTIVATION: Comparing the 3D structures of two proteins or analyzing the structural changes undergone by a protein upon ligand binding or when it crystallizes under different conditions, can be both tricky and tedious, especially when the two proteins are distantly related, or when the structural changes are complex. Readily accessible tools for performing these tasks automatically and reliably should therefore be welcome. RESULTS: We describe a web interface to several automatic procedures for performing pairwise structure superposition in a flexible manner, for detailed analyses of conformational changes and for displaying the results in a pictorial fashion. AVAILABILITY: This interface can be accessed at the Brussels and Cuba Web sites, respectively: http://www.ucmb.ulb.ac.be/SCMBB/Tools.htmland http://bio.cigb.edu.cu.
