Assuntos
Proteínas de Transporte/genética , Cães/genética , Ligação Genética , Mapeamento Físico do Cromossomo/veterinária , Proteínas/genética , Animais , Fator Apoptótico 1 Ativador de Proteases , Sequência de Bases , Primers do DNA , Proteínas de Ligação a Fosfato , Reação em Cadeia da PolimeraseRESUMO
Life-threatening illness now qualifies as a precipitating stessor for posttraumatic stress disorder (PTSD). We examined the validity of the PTSD Checklist-Civilian Version (PCL-C; Weathers, Litz, Herman, Juska, & Keane, 1993), a brief 17-item inventory of PTSD-like symptoms, in a sample of 111 adults who had undergone bone marrow transplantation an average of 4.04 years previously. Exploratory factor analysis of the PCL-C identified four distinct patterns of symptom responses: Numbing-Hyperarousal, Dreams-Memories of the Cancer Treatment, General Hyperarousal, Responses to Cancer-Related Reminders and Avoidance-Numbing. Respondents meeting PTSD symptom criteria on the PCL-C had significantly lower physical, role, and social functioning, greater distress and anxiety, and significantly more intrusive and avoidant responses than individuals who did not meet PTSD symptom criteria.
Assuntos
Transplante de Medula Óssea/psicologia , Transtornos de Estresse Pós-Traumáticos/diagnóstico , Transtornos de Estresse Pós-Traumáticos/psicologia , Inquéritos e Questionários/normas , Sobreviventes/psicologia , Atividades Cotidianas , Adolescente , Adulto , Nível de Alerta , Atitude Frente a Saúde , Aprendizagem da Esquiva , Transplante de Medula Óssea/efeitos adversos , Análise Discriminante , Análise Fatorial , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Dor/etiologia , Fatores Desencadeantes , Psicometria , Reprodutibilidade dos Testes , Transtornos de Estresse Pós-Traumáticos/etiologiaRESUMO
The relationship between the therapeutic use of potentially abusable drugs for symptom control and the multifaceted nature of abuse and addiction is extremely complex. Research is only beginning to elucidate the nature of this relationship and its clinical implications. At present, practical management is based primarily on clinical experience and anecdotal observations. In part I of this two-part series (published last month), the authors explored the epidemiology of substance abuse in the cancer population, provided definitions of addiction and abuse appropriate for the oncology setting, and offered guidelines for the assessment of aberrant drug-taking behavior. In this second part, the authors provide recommendations for the evaluation and treatment of patients with cancer who have a history of substance abuse. Suggested therapeutic goals are outlined, and plans for inpatient and outpatient management and detailed.
Assuntos
Neoplasias/complicações , Transtornos Relacionados ao Uso de Substâncias/complicações , Pessoal de Saúde , Humanos , Neoplasias/psicologia , Neoplasias/terapia , Transtornos Relacionados ao Uso de Substâncias/psicologiaRESUMO
Although rare, drug abuse problems present a complex set of physical and psychosocial issues that complicate cancer treatment and pain/ symptom management. Most oncologists are not be well versed in either the conceptual or practical issues related to addiction. As a result, they often struggle in their attempts to effectively treat patients who are or have been substance abusers, and they find it difficult to understand issues of addiction in patients with pain who have no history of substance abuse. In the first installment of a two-part series, the authors explore the epidemiology of substance abuse. An examination of the distinctions between abuse and dependence leads to definitions of these terms appropriate for the oncology setting. Guidelines for assessing aberrant drug-taking behavior are also offered. Part 2, which will appear in the next issue of ONCOLOGY, will discuss the clinical management of cancer patients with a history of substance abuse.
