1.
Diabetologia
; 51(4): 689-91, 2008 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18210080
2.
Pharmazie
; 53(9): 620-4, 1998 Sep.
Artigo
em Alemão
| MEDLINE
| ID: mdl-9770210
RESUMO
Chlormezanone, a chiral centrally acting muscle relaxant, will be cleaved at its S-C-1 bond by an autoprotolytic process. The optimum of chemical stability exists between pH 2 up to pH 9 with a maximum at pH 7.4. The plasma half life at 37 degrees C is 76 h. Enzymes do attack the products of cleavage namely 4-chlorobenzaldehyde and 2-carboxyethane-sulfinic-acid-N-methyl-amide. The main metabolite in urine is 4-chlorohippuric acid in the range of up to 70% of the oral administered dose to humans. No cytochrome P-450 is engaged in the cleavage of the S-C-bond.
Assuntos
Clormezanona/farmacocinética , Relaxantes Musculares Centrais/farmacocinética , Biotransformação , Cromatografia Líquida de Alta Pressão , Meia-Vida , Humanos
3.
Med Klin Suppl
; 3: 16-7, 1986 Oct.
Artigo
em Alemão
| MEDLINE
| ID: mdl-3470589
4.
Med Klin Suppl
; 3: 8-10, 1986 Oct.
Artigo
em Alemão
| MEDLINE
| ID: mdl-3550368